Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy.

Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy.

Precision medicine requires accurate technologies for drug administration and proper systems pharmacology approaches for patient data analysis. Here, plasma pharmacokinetics (PK) data of the OPTILIV trial in which cancer patients received oxaliplatin, 5-fluorouracil and irinotecan via chronomodulate...

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Bibliographic Details
Main Authors: Roger J W Hill, Pasquale F Innominato, Francis Lévi, Annabelle Ballesta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Computational Biology
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007218/2/pcbi.1007218.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210219%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210219T121348Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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