Silencing LncRNA HCG27 ameliorates cognitive dysfunction after ischemic stroke via miR-27a-3p regulation

Silencing LncRNA HCG27 ameliorates cognitive dysfunction after ischemic stroke via miR-27a-3p regulation

Abstract Background We explore the effect of improving cognitive dysfunction after cerebral ischemia–reperfusion (CI/R) by regulating HCG27. Methods The MCAO and OGD/R methods were employed to establish in vivo and in vitro models of cognitive dysfunction caused by a CI/R injury. RT-qPCR was utilize...

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Bibliographic Details
Main Authors: Ting Li, Ying Li, Lin Chen, Chaosheng Zeng, Huaijie Xing, Min Chen, Limin Yan, Xiaopei Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Hereditas
Subjects:
HCG27
miR-27a-3p
Cognitive dysfunction
Cerebrovascular disease
Cerebral ischemia-reperfusion
Online Access:https://doi.org/10.1186/s41065-025-00493-6
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