Trans-ethnic Mendelian randomization analysis of membranous nephropathy and peripheral artery disease with mediating effects of thrombomodulin

Trans-ethnic Mendelian randomization analysis of membranous nephropathy and peripheral artery disease with mediating effects of thrombomodulin

Abstract This study employed a trans-ethnic two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between membranous nephropathy (MN) and peripheral artery disease (PAD). In European populations, MN exhibited a significant positive causal effect on PAD (discovery: O...

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Bibliographic Details
Main Authors: Juhong Pan, Xingyue Huang, Yueying Chen, Nan Jiang, Yuxin Guo, Shiyuan Zhou, Yao Zhang, Bo Hu, Qing Deng, Qing Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Peripheral artery disease
Membranous nephropathy
Thrombomodulin
Mediation
Mendelian randomization
Online Access:https://doi.org/10.1038/s41598-025-02626-3
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