Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

IntroductionChitin is a highly abundant polysaccharide in nature and is linked to immune recognition of fungal infections and asthma in humans. Ubiquitous in fungi and insects, chitin is absent inmammals and plants and, thus, represents a microbeassociatedmolecular pattern (MAMP). However, highly po...

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Main Authors:	Tzu-Hsuan Chang, Yamel Cardona Gloria, Margareta J. Hellmann, Timmy Richardo, Carsten Leo Greve, Didier Le Roy, Thierry Roger, Francesca Bork, Stefanie Bugl, Johanna Jakob, Johannes Sonnberger, Lydia Kasper, Bernhard Hube, Stefan Pusch, Neil A. R. Gow, Morten Sørlie, Anne Tøndervik, Bruno M. Moerschbacher, Alexander N. R. Weber
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Immunology
Subjects:	chitin chitotriosidase N-acetyl-glucosamine Toll-like receptor (TLR) inflammation myeloid cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1497174/full
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Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

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