Acute Liver Failure due to Disseminated Varicella Zoster Infection
Acute liver failure (ALF) can be due to numerous causes and result in fatality or necessitate liver transplantation if left untreated. Possible etiologies of ALF include ischemia, venous obstruction, medications, toxins, autoimmune hepatitis, metabolic and infectious causes including hepatitis A-E,...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/1269340 |
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| _version_ | 1850220139171020800 |
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| author | Elizabeth Caitlin Brewer Leigh Hunter |
| author_facet | Elizabeth Caitlin Brewer Leigh Hunter |
| author_sort | Elizabeth Caitlin Brewer |
| collection | DOAJ |
| description | Acute liver failure (ALF) can be due to numerous causes and result in fatality or necessitate liver transplantation if left untreated. Possible etiologies of ALF include ischemia, venous obstruction, medications, toxins, autoimmune hepatitis, metabolic and infectious causes including hepatitis A-E, varicella-zoster virus (VZV), cytomegalovirus (CMV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), and adenovirus with VZV being the most rarely reported. Pathognomonic skin lesions facilitate diagnosis of VZV hepatitis, but definitive diagnosis is secured with liver biopsy, tissue histopathology, culture, and specific VZV polymerase chain reaction (PCR). Antiviral treatment with intravenous acyclovir can be effective if initiated in a timely manner; however, comorbidities and complications frequently result in high mortality, especially in immunocompromised hosts as exemplified in this case presentation. |
| format | Article |
| id | doaj-art-776b35cd1ae94c61bbb026990cd8ae70 |
| institution | OA Journals |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-776b35cd1ae94c61bbb026990cd8ae702025-08-20T02:07:09ZengWileyCase Reports in Hepatology2090-65872090-65952018-01-01201810.1155/2018/12693401269340Acute Liver Failure due to Disseminated Varicella Zoster InfectionElizabeth Caitlin Brewer0Leigh Hunter1Methodist Hospitals of Dallas, 1441 N Beckley Ave Dallas, TX 75203, USAMethodist Hospitals of Dallas, 1441 N Beckley Ave Dallas, TX 75203, USAAcute liver failure (ALF) can be due to numerous causes and result in fatality or necessitate liver transplantation if left untreated. Possible etiologies of ALF include ischemia, venous obstruction, medications, toxins, autoimmune hepatitis, metabolic and infectious causes including hepatitis A-E, varicella-zoster virus (VZV), cytomegalovirus (CMV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), and adenovirus with VZV being the most rarely reported. Pathognomonic skin lesions facilitate diagnosis of VZV hepatitis, but definitive diagnosis is secured with liver biopsy, tissue histopathology, culture, and specific VZV polymerase chain reaction (PCR). Antiviral treatment with intravenous acyclovir can be effective if initiated in a timely manner; however, comorbidities and complications frequently result in high mortality, especially in immunocompromised hosts as exemplified in this case presentation.http://dx.doi.org/10.1155/2018/1269340 |
| spellingShingle | Elizabeth Caitlin Brewer Leigh Hunter Acute Liver Failure due to Disseminated Varicella Zoster Infection Case Reports in Hepatology |
| title | Acute Liver Failure due to Disseminated Varicella Zoster Infection |
| title_full | Acute Liver Failure due to Disseminated Varicella Zoster Infection |
| title_fullStr | Acute Liver Failure due to Disseminated Varicella Zoster Infection |
| title_full_unstemmed | Acute Liver Failure due to Disseminated Varicella Zoster Infection |
| title_short | Acute Liver Failure due to Disseminated Varicella Zoster Infection |
| title_sort | acute liver failure due to disseminated varicella zoster infection |
| url | http://dx.doi.org/10.1155/2018/1269340 |
| work_keys_str_mv | AT elizabethcaitlinbrewer acuteliverfailureduetodisseminatedvaricellazosterinfection AT leighhunter acuteliverfailureduetodisseminatedvaricellazosterinfection |