Identification and characterization of cell niches in tissue from spatial omics data at single-cell resolution

Abstract Deciphering the features, structure, and functions of the cell niche in tissues remains a major challenge. Here, we present scNiche, a computational framework to identify and characterize cell niches from spatial omics data at single-cell resolution. We benchmark scNiche with both simulated...

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Bibliographic Details
Main Authors: Jingyang Qian, Xin Shao, Hudong Bao, Yin Fang, Wenbo Guo, Chengyu Li, Anyao Li, Hua Hua, Xiaohui Fan
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57029-9
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