Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis
Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes. However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis. The me...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3262384 |
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| author | Geng Yin Ying Wang Xiao-min Cen Yuan Yang Min Yang Qi-bing Xie |
| author_facet | Geng Yin Ying Wang Xiao-min Cen Yuan Yang Min Yang Qi-bing Xie |
| author_sort | Geng Yin |
| collection | DOAJ |
| description | Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes. However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis. The mechanistic target of rapamycin (mTOR) signaling is the central regulator of metabolism and inflammation in mammalian cells. Based on previous studies, we proposed that mTOR signaling may control inflammatory reactions via lipid metabolism. In this study, we aim to figure out the role of mTOR signaling in the development of polymyositis and identify novel biomarkers for the detection and therapy of polymyositis. After screening and validation, we found that palmitoleic acid, a monounsaturated fatty acid, is highly regulated by mTOR signaling. Inhibition of mTORC1 activity decreases palmitoleic acid level. Moreover, mTORC1 regulates the level of palmitoleic acid by controlling its de novo synthesis. Importantly, increased palmitoleic acid has been proven to be a marker of polymyositis. Our work identifies palmitoleic acid in peripheral blood mononuclear cells (PBMC) as a biomarker of polymyositis and offers new targets to the clinical therapy. |
| format | Article |
| id | doaj-art-7762c5ff3bcb4e5d8cb3c1f64fd59580 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-7762c5ff3bcb4e5d8cb3c1f64fd595802025-08-20T03:35:37ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/32623843262384Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of PolymyositisGeng Yin0Ying Wang1Xiao-min Cen2Yuan Yang3Min Yang4Qi-bing Xie5Department of General Medicine, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu 610041, ChinaPolymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes. However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis. The mechanistic target of rapamycin (mTOR) signaling is the central regulator of metabolism and inflammation in mammalian cells. Based on previous studies, we proposed that mTOR signaling may control inflammatory reactions via lipid metabolism. In this study, we aim to figure out the role of mTOR signaling in the development of polymyositis and identify novel biomarkers for the detection and therapy of polymyositis. After screening and validation, we found that palmitoleic acid, a monounsaturated fatty acid, is highly regulated by mTOR signaling. Inhibition of mTORC1 activity decreases palmitoleic acid level. Moreover, mTORC1 regulates the level of palmitoleic acid by controlling its de novo synthesis. Importantly, increased palmitoleic acid has been proven to be a marker of polymyositis. Our work identifies palmitoleic acid in peripheral blood mononuclear cells (PBMC) as a biomarker of polymyositis and offers new targets to the clinical therapy.http://dx.doi.org/10.1155/2017/3262384 |
| spellingShingle | Geng Yin Ying Wang Xiao-min Cen Yuan Yang Min Yang Qi-bing Xie Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis Journal of Immunology Research |
| title | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
| title_full | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
| title_fullStr | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
| title_full_unstemmed | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
| title_short | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
| title_sort | identification of palmitoleic acid controlled by mtor signaling as a biomarker of polymyositis |
| url | http://dx.doi.org/10.1155/2017/3262384 |
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