Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche

Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche

Abstract Metastasis in cancer is influenced by epigenetic factors. Using an in vivo screen, we demonstrate that several subunits of the polybromo-associated BAF (PBAF) chromatin remodeling complex, particularly Brd7, are required for maintaining breast cancer metastatic dormancy in the lungs of fema...

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Bibliographic Details
Main Authors: Jayanta Mondal, Junfeng Zhang, Feng Qing, Shunping Li, Dhiraj Kumar, Jason T. Huse, Filippo G. Giancotti
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56347-2
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