Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer Center

Introduction Palbociclib, the first CDK4/6 inhibitor, has shown promising results in phase III clinical studies by enhancing the efficacy of endocrine therapy (ET) in HR +/HER2– advanced breast cancer. However, real-world data on its use in patients with visceral metastatic disease are li...

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Main Authors: Sandeep K. S, Sandhya Appachu, Ravi B. Diwaker, Sai Vivek, Vijai V.S. Simha
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2025-04-01
Series:Indian Journal of Medical and Paediatric Oncology
Subjects:
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1790584
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author Sandeep K. S
Sandhya Appachu
Ravi B. Diwaker
Sai Vivek
Vijai V.S. Simha
author_facet Sandeep K. S
Sandhya Appachu
Ravi B. Diwaker
Sai Vivek
Vijai V.S. Simha
author_sort Sandeep K. S
collection DOAJ
description Introduction Palbociclib, the first CDK4/6 inhibitor, has shown promising results in phase III clinical studies by enhancing the efficacy of endocrine therapy (ET) in HR +/HER2– advanced breast cancer. However, real-world data on its use in patients with visceral metastatic disease are limited. We aimed to assess the effectiveness and tolerability of palbociclib in this high-risk population across different lines of treatment.
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publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
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series Indian Journal of Medical and Paediatric Oncology
spelling doaj-art-775ff33e236f47bdb32c70a14f2442012025-08-20T02:32:44ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292025-04-01460216817310.1055/s-0044-1790584Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer CenterSandeep K. S0https://orcid.org/0000-0003-2110-1233Sandhya Appachu1Ravi B. Diwaker2Sai Vivek3Vijai V.S. Simha4Department of Medical Oncology, Sri Shankara Cancer Hospital and Research Centre, Bengaluru, Karnataka, IndiaDepartment of Medical Oncology, Sri Shankara Cancer Hospital and Research Centre, Bengaluru, Karnataka, IndiaDepartment of Medical Oncology, Sri Shankara Cancer Hospital and Research Centre, Bengaluru, Karnataka, IndiaDepartment of Medical Oncology, Sri Shankara Cancer Hospital and Research Centre, Bengaluru, Karnataka, IndiaDepartment of Medical Oncology, Sri Shankara Cancer Hospital and Research Centre, Bengaluru, Karnataka, India Introduction Palbociclib, the first CDK4/6 inhibitor, has shown promising results in phase III clinical studies by enhancing the efficacy of endocrine therapy (ET) in HR +/HER2– advanced breast cancer. However, real-world data on its use in patients with visceral metastatic disease are limited. We aimed to assess the effectiveness and tolerability of palbociclib in this high-risk population across different lines of treatment.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1790584CDK4/6 inhibitorspalbociclibvisceral metastatic breast cancermetastatic hormone-positive breast cancer
spellingShingle Sandeep K. S
Sandhya Appachu
Ravi B. Diwaker
Sai Vivek
Vijai V.S. Simha
Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer Center
Indian Journal of Medical and Paediatric Oncology
CDK4/6 inhibitors
palbociclib
visceral metastatic breast cancer
metastatic hormone-positive breast cancer
title Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer Center
title_full Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer Center
title_fullStr Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer Center
title_full_unstemmed Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer Center
title_short Clinical Benefit and Safety of Palbociclib in Hormone Positive Breast Cancer with Visceral Metastasis: Real-World Experience from a Tertiary Cancer Center
title_sort clinical benefit and safety of palbociclib in hormone positive breast cancer with visceral metastasis real world experience from a tertiary cancer center
topic CDK4/6 inhibitors
palbociclib
visceral metastatic breast cancer
metastatic hormone-positive breast cancer
url http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1790584
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