Aging and diet alter the protein ubiquitylation landscape in the mouse brain

Aging and diet alter the protein ubiquitylation landscape in the mouse brain

Abstract Post-translational modifications (PTMs) regulate protein homeostasis, but how aging impacts PTMs remains unclear. Here, we used mass spectrometry to reveal changes in hundreds of protein ubiquitylation, acetylation, and phosphorylation sites in the mouse aging brain. We show that aging has...

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Bibliographic Details
Main Authors: Antonio Marino, Domenico Di Fraia, Diana Panfilova, Amit Kumar Sahu, Alberto Minetti, Omid Omrani, Emilio Cirri, Alessandro Ori
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60542-6
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