Aminoquinazolin-4(3H)-one derivatives as multitargeting therapeutics in Alzheimer's disease

Aminoquinazolin-4(3H)-one derivatives as multitargeting therapeutics in Alzheimer's disease

Alzheimer's disease (AD) is one of the most debilitating forms of amyloidogenesis-induced dementia, and innovative, effective scaffolds are required for its treatment. Monoamine oxidase B (MAO-B) contributes to Alzheimer's by oxidizing monoamines and generating reactive oxygen species, the...

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Bibliographic Details
Main Authors:	Tajamul Hussain, Salman Alrokayan, Dilawar Hussain, Khurram Shoaib, Syeda Abida Ejaz, Steven Ford, Jamshed Iqbal
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Series:	Results in Chemistry
Subjects:	Alzheimer's disease Aminoquinazolinone BACE1 Inhibition Molecular docking MD simulations
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715625003261
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