Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial Infarction
Background Recent evidence highlights an increasing incidence of myocardial infarction in young women. Identifying clinical multimorbidity patterns in this population may improve therapeutic strategies and clinical care. Methods and Results We identified multimorbidity patterns in 9570 young women w...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.034124 |
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| author | Geru A Liang Zhao Wennan Liu Pengfei Sun Linjie Li Bin Sun Piao Li Yongle Li Xin Zhou Qing Yang |
| author_facet | Geru A Liang Zhao Wennan Liu Pengfei Sun Linjie Li Bin Sun Piao Li Yongle Li Xin Zhou Qing Yang |
| author_sort | Geru A |
| collection | DOAJ |
| description | Background Recent evidence highlights an increasing incidence of myocardial infarction in young women. Identifying clinical multimorbidity patterns in this population may improve therapeutic strategies and clinical care. Methods and Results We identified multimorbidity patterns in 9570 young women with ST‐segment–elevation myocardial infarction (median age, 50 years [range, 47.0–53.0 years]) admitted to the China Chest Pain Center Database between 2016 and 2021. Hierarchical clustering of 15 medical conditions was performed to derive multimorbidity patterns. The primary outcome was a composite of in‐hospital adverse events. Associations between multimorbidity patterns and outcomes were evaluated using multivariable‐adjusted logistic regression models. Among 9570 patients, 50% (n=4789) had multimorbidity. Six multimorbidity patterns were identified, including 4 specific patterns: (1) pattern 1, cerebrovascular cluster (histories of cerebrovascular disease and hypertension); (2) pattern 2, traditional cardiovascular disease risk factors cluster (histories of hyperlipidemia, obesity, and diabetes, and family history of cardiovascular disease and smoking); (3) pattern 3, coronary‐heart failure cluster (histories of heart failure, coronary artery disease, peripheral arterial disease, and thyroid dysfunction); and (4) pattern 4, anemia‐renal dysfunction cluster (histories of atrial fibrillation, anemia, chronic kidney disease, and peptic ulcer). Compared with patients without multimorbidity, those with pattern 1 (odds ratio [OR], 2.29 [95% CI, 1.49–3.52]), pattern 2 (OR, 1.52 [95% CI, 1.24–1.86]), and pattern 4 (OR, 2.25 [95% CI, 1.10–4.61]) exhibited higher risks for composite outcomes. Conclusions Specific multimorbidity patterns in young women with ST‐segment–elevation myocardial infarction were associated with distinct in‐hospital outcomes in a nationwide registry, providing proof‐of‐concept evidence to guide future therapeutic approaches. |
| format | Article |
| id | doaj-art-775ed99e87274c39bab3df3ba570bcbd |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-775ed99e87274c39bab3df3ba570bcbd2025-08-20T03:24:52ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-04-0114710.1161/JAHA.124.034124Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial InfarctionGeru A0Liang Zhao1Wennan Liu2Pengfei Sun3Linjie Li4Bin Sun5Piao Li6Yongle Li7Xin Zhou8Qing Yang9Department of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaBackground Recent evidence highlights an increasing incidence of myocardial infarction in young women. Identifying clinical multimorbidity patterns in this population may improve therapeutic strategies and clinical care. Methods and Results We identified multimorbidity patterns in 9570 young women with ST‐segment–elevation myocardial infarction (median age, 50 years [range, 47.0–53.0 years]) admitted to the China Chest Pain Center Database between 2016 and 2021. Hierarchical clustering of 15 medical conditions was performed to derive multimorbidity patterns. The primary outcome was a composite of in‐hospital adverse events. Associations between multimorbidity patterns and outcomes were evaluated using multivariable‐adjusted logistic regression models. Among 9570 patients, 50% (n=4789) had multimorbidity. Six multimorbidity patterns were identified, including 4 specific patterns: (1) pattern 1, cerebrovascular cluster (histories of cerebrovascular disease and hypertension); (2) pattern 2, traditional cardiovascular disease risk factors cluster (histories of hyperlipidemia, obesity, and diabetes, and family history of cardiovascular disease and smoking); (3) pattern 3, coronary‐heart failure cluster (histories of heart failure, coronary artery disease, peripheral arterial disease, and thyroid dysfunction); and (4) pattern 4, anemia‐renal dysfunction cluster (histories of atrial fibrillation, anemia, chronic kidney disease, and peptic ulcer). Compared with patients without multimorbidity, those with pattern 1 (odds ratio [OR], 2.29 [95% CI, 1.49–3.52]), pattern 2 (OR, 1.52 [95% CI, 1.24–1.86]), and pattern 4 (OR, 2.25 [95% CI, 1.10–4.61]) exhibited higher risks for composite outcomes. Conclusions Specific multimorbidity patterns in young women with ST‐segment–elevation myocardial infarction were associated with distinct in‐hospital outcomes in a nationwide registry, providing proof‐of‐concept evidence to guide future therapeutic approaches.https://www.ahajournals.org/doi/10.1161/JAHA.124.034124cardiovascular eventsChinesefemalemultimorbidityST‐segment–elevation myocardial infarction |
| spellingShingle | Geru A Liang Zhao Wennan Liu Pengfei Sun Linjie Li Bin Sun Piao Li Yongle Li Xin Zhou Qing Yang Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial Infarction Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular events Chinese female multimorbidity ST‐segment–elevation myocardial infarction |
| title | Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial Infarction |
| title_full | Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial Infarction |
| title_fullStr | Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial Infarction |
| title_full_unstemmed | Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial Infarction |
| title_short | Multimorbidity Patterns and In‐Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST‐Segment–Elevation Myocardial Infarction |
| title_sort | multimorbidity patterns and in hospital outcomes in chinese young women aged 55 years presenting with st segment elevation myocardial infarction |
| topic | cardiovascular events Chinese female multimorbidity ST‐segment–elevation myocardial infarction |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.034124 |
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