Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment
Liver diseases pose a significant threat to human health. Lactate, a byproduct of glycolysis, serves various biological functions, including acting as an energy source, a signaling molecule, and a substrate for lactylation. Lactylation is a novel lactate-dependent post-translational modification tha...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1581582/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850189885761126400 |
|---|---|
| author | Shiyi Cheng Xiaoyu Xiao Dingye Wang Xiyuan Wang Minlan Yang |
| author_facet | Shiyi Cheng Xiaoyu Xiao Dingye Wang Xiyuan Wang Minlan Yang |
| author_sort | Shiyi Cheng |
| collection | DOAJ |
| description | Liver diseases pose a significant threat to human health. Lactate, a byproduct of glycolysis, serves various biological functions, including acting as an energy source, a signaling molecule, and a substrate for lactylation. Lactylation is a novel lactate-dependent post-translational modification that plays a role in tumor proliferation, the regulation of immune cell function, and the modulation of gene expression. In this paper, we summarize the roles of lactate and lactylation in energy metabolism, inflammatory immunity, and the tumor microenvironment, while also elucidating recent research advancements regarding lactate and lactylation in the context of hepatic fibrosis, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, lactate and lactylation are proposed as promising new targets for the treatment of liver diseases. |
| format | Article |
| id | doaj-art-775ed2b34c1145dc9d0e0101af763e41 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-775ed2b34c1145dc9d0e0101af763e412025-08-20T02:15:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15815821581582Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironmentShiyi ChengXiaoyu XiaoDingye WangXiyuan WangMinlan YangLiver diseases pose a significant threat to human health. Lactate, a byproduct of glycolysis, serves various biological functions, including acting as an energy source, a signaling molecule, and a substrate for lactylation. Lactylation is a novel lactate-dependent post-translational modification that plays a role in tumor proliferation, the regulation of immune cell function, and the modulation of gene expression. In this paper, we summarize the roles of lactate and lactylation in energy metabolism, inflammatory immunity, and the tumor microenvironment, while also elucidating recent research advancements regarding lactate and lactylation in the context of hepatic fibrosis, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, lactate and lactylation are proposed as promising new targets for the treatment of liver diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1581582/fulllactatelactylationliver diseasesmetabolismimmunology |
| spellingShingle | Shiyi Cheng Xiaoyu Xiao Dingye Wang Xiyuan Wang Minlan Yang Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment Frontiers in Immunology lactate lactylation liver diseases metabolism immunology |
| title | Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment |
| title_full | Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment |
| title_fullStr | Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment |
| title_full_unstemmed | Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment |
| title_short | Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment |
| title_sort | lactate and lactylation in liver diseases energy metabolism inflammatory immunity and tumor microenvironment |
| topic | lactate lactylation liver diseases metabolism immunology |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1581582/full |
| work_keys_str_mv | AT shiyicheng lactateandlactylationinliverdiseasesenergymetabolisminflammatoryimmunityandtumormicroenvironment AT xiaoyuxiao lactateandlactylationinliverdiseasesenergymetabolisminflammatoryimmunityandtumormicroenvironment AT dingyewang lactateandlactylationinliverdiseasesenergymetabolisminflammatoryimmunityandtumormicroenvironment AT xiyuanwang lactateandlactylationinliverdiseasesenergymetabolisminflammatoryimmunityandtumormicroenvironment AT minlanyang lactateandlactylationinliverdiseasesenergymetabolisminflammatoryimmunityandtumormicroenvironment |