Variations in salivary microbiome and metabolites are associated with immunotherapy efficacy in patients with advanced NSCLC

Variations in salivary microbiome and metabolites are associated with immunotherapy efficacy in patients with advanced NSCLC

ABSTRACT Lung cancer is a leading cause of cancer mortality, with non-small cell lung cancer (NSCLC) comprising the majority of cases. Despite the advent of immune checkpoint inhibitors (ICIs), a significant number of patients fail to achieve a durable response, highlighting the need to understand t...

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Main Authors: DanHui Huang, YueHua Chen, Cui Li, Shuang Yang, LiShan Lin, XiaoNan Zhang, XiaoFang Su, LaiYu Liu, Haijin Zhao, Tingyue Luo, Shaoxi Cai, QianNan Ren, Hangming Dong
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mSystems
Subjects:
saliva microbiome
fat metabolism
immunotherapy response
non-small cell lung cancer
Online Access:https://journals.asm.org/doi/10.1128/msystems.01115-24
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