Cytokines and Angiogenesis in the Corpus Luteum
In adults, physiological angiogenesis is a rare event, with few exceptions as the vasculogenesis needed for tissue growth and function in female reproductive organs. Particularly in the corpus luteum (CL), regulation of angiogenic process seems to be tightly controlled by opposite actions resultant...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/420186 |
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| author | António M. Galvão Graça Ferreira-Dias Dariusz J. Skarzynski |
| author_facet | António M. Galvão Graça Ferreira-Dias Dariusz J. Skarzynski |
| author_sort | António M. Galvão |
| collection | DOAJ |
| description | In adults, physiological angiogenesis is a rare event, with few exceptions as the vasculogenesis needed for tissue growth and function in female reproductive organs. Particularly in the corpus luteum (CL), regulation of angiogenic process seems to be tightly controlled by opposite actions resultant from the balance between pro- and antiangiogenic factors. It is the extremely rapid sequence of events that determines the dramatic changes on vascular and nonvascular structures, qualifying the CL as a great model for angiogenesis studies. Using the mare CL as a model, reports on locally produced cytokines, such as tumor necrosis factor α (TNF), interferon gamma (IFNG), or Fas ligand (FASL), pointed out their role on angiogenic activity modulation throughout the luteal phase. Thus, the main purpose of this review is to highlight the interaction between immune, endothelial, and luteal steroidogenic cells, regarding vascular dynamics/changes during establishment and regression of the equine CL. |
| format | Article |
| id | doaj-art-77596eb52a7042a1a2b7d9b994af124c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-77596eb52a7042a1a2b7d9b994af124c2025-02-03T01:00:36ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/420186420186Cytokines and Angiogenesis in the Corpus LuteumAntónio M. Galvão0Graça Ferreira-Dias1Dariusz J. Skarzynski2CIISA, Department of Morphology and Function, Faculty of Veterinary Medicine, Technical University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisboa, PortugalCIISA, Department of Morphology and Function, Faculty of Veterinary Medicine, Technical University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisboa, PortugalInstitute of Animal Reproduction and Food Research of PAS, Ulica Bydgoska 7, 10-243 Olsztyn, PolandIn adults, physiological angiogenesis is a rare event, with few exceptions as the vasculogenesis needed for tissue growth and function in female reproductive organs. Particularly in the corpus luteum (CL), regulation of angiogenic process seems to be tightly controlled by opposite actions resultant from the balance between pro- and antiangiogenic factors. It is the extremely rapid sequence of events that determines the dramatic changes on vascular and nonvascular structures, qualifying the CL as a great model for angiogenesis studies. Using the mare CL as a model, reports on locally produced cytokines, such as tumor necrosis factor α (TNF), interferon gamma (IFNG), or Fas ligand (FASL), pointed out their role on angiogenic activity modulation throughout the luteal phase. Thus, the main purpose of this review is to highlight the interaction between immune, endothelial, and luteal steroidogenic cells, regarding vascular dynamics/changes during establishment and regression of the equine CL.http://dx.doi.org/10.1155/2013/420186 |
| spellingShingle | António M. Galvão Graça Ferreira-Dias Dariusz J. Skarzynski Cytokines and Angiogenesis in the Corpus Luteum Mediators of Inflammation |
| title | Cytokines and Angiogenesis in the Corpus Luteum |
| title_full | Cytokines and Angiogenesis in the Corpus Luteum |
| title_fullStr | Cytokines and Angiogenesis in the Corpus Luteum |
| title_full_unstemmed | Cytokines and Angiogenesis in the Corpus Luteum |
| title_short | Cytokines and Angiogenesis in the Corpus Luteum |
| title_sort | cytokines and angiogenesis in the corpus luteum |
| url | http://dx.doi.org/10.1155/2013/420186 |
| work_keys_str_mv | AT antoniomgalvao cytokinesandangiogenesisinthecorpusluteum AT gracaferreiradias cytokinesandangiogenesisinthecorpusluteum AT dariuszjskarzynski cytokinesandangiogenesisinthecorpusluteum |