Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i>
Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A–E (<b>1</b>–<b>5</b>), were isolated...
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MDPI AG
2024-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/22/12/536 |
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| author | Hanyang Peng Yanbo Zeng Rui Zhang Li Yang Fei Wu Cuijuan Gai Jingzhe Yuan Wenjun Chang Haofu Dai Xiachang Wang |
| author_facet | Hanyang Peng Yanbo Zeng Rui Zhang Li Yang Fei Wu Cuijuan Gai Jingzhe Yuan Wenjun Chang Haofu Dai Xiachang Wang |
| author_sort | Hanyang Peng |
| collection | DOAJ |
| description | Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A–E (<b>1</b>–<b>5</b>), were isolated from the soft coral <i>Sarcophyton crassocaule</i>, along with five previously reported compounds (<b>6</b>–<b>10</b>). The structures and absolute configuration for new compounds <b>1</b>–<b>5</b> were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds <b>3</b>, <b>4</b>, and <b>9</b> showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds. |
| format | Article |
| id | doaj-art-7754341f6af64ae59fa114f65760b1da |
| institution | DOAJ |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-7754341f6af64ae59fa114f65760b1da2025-08-20T02:57:02ZengMDPI AGMarine Drugs1660-33972024-11-01221253610.3390/md22120536Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i>Hanyang Peng0Yanbo Zeng1Rui Zhang2Li Yang3Fei Wu4Cuijuan Gai5Jingzhe Yuan6Wenjun Chang7Haofu Dai8Xiachang Wang9Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaJiangsu Key Laboratory for Functional Substances of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaJiangsu Key Laboratory for Functional Substances of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A–E (<b>1</b>–<b>5</b>), were isolated from the soft coral <i>Sarcophyton crassocaule</i>, along with five previously reported compounds (<b>6</b>–<b>10</b>). The structures and absolute configuration for new compounds <b>1</b>–<b>5</b> were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds <b>3</b>, <b>4</b>, and <b>9</b> showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.https://www.mdpi.com/1660-3397/22/12/536soft coralcembranoid diterpenestructural elucidationabsolute configurationanti-inflammatory activity |
| spellingShingle | Hanyang Peng Yanbo Zeng Rui Zhang Li Yang Fei Wu Cuijuan Gai Jingzhe Yuan Wenjun Chang Haofu Dai Xiachang Wang Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i> Marine Drugs soft coral cembranoid diterpene structural elucidation absolute configuration anti-inflammatory activity |
| title | Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i> |
| title_full | Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i> |
| title_fullStr | Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i> |
| title_full_unstemmed | Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i> |
| title_short | Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i> |
| title_sort | cembranoid diterpenes from south china sea soft coral i sarcophyton crassocaule i |
| topic | soft coral cembranoid diterpene structural elucidation absolute configuration anti-inflammatory activity |
| url | https://www.mdpi.com/1660-3397/22/12/536 |
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