Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice

Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice

BackgroundThe purpose of this study was to explore how semaglutide, a GLP-1RA, regulates serum metabolism and gut microbiota to improve obesity in mice and whether fecal microbiota transplantation (FMT) can transmit the beneficial effects of semaglutide to recipient mice.MethodsMale C57BL/6J mice we...

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Bibliographic Details
Main Authors: Luyan Sun, Bingqing Shang, Suyuan Lv, Guolong Liu, Qiu Wu, Yue Geng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
obesity
semaglutide
gut microbiota
metabolomics
fecal microbiota transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1562896/full
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