Hybrid model integration with explainable AI for brain tumor diagnosis: a unified approach to MRI analysis and prediction

Abstract Effective treatment for brain tumors relies on accurate detection because this is a crucial health condition. Medical imaging plays a pivotal role in improving tumor detection and diagnosis in the early stage. This study presents two approaches to the tumor detection problem focusing on the...

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Bibliographic Details
Main Authors: D. Vamsidhar, Parth Desai, Sagar Joshi, Shrikrishna Kolhar, Nilkanth Deshpande, Shilpa Gite
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-06455-2
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Summary:Abstract Effective treatment for brain tumors relies on accurate detection because this is a crucial health condition. Medical imaging plays a pivotal role in improving tumor detection and diagnosis in the early stage. This study presents two approaches to the tumor detection problem focusing on the healthcare domain. A combination of image processing, vision transformer (ViT), and machine learning algorithms is the first approach that focuses on analyzing medical images. The second approach is the parallel model integration technique, where we first integrate two pre-trained deep learning models, ResNet101, and Xception, followed by applying local interpretable model-agnostic explanations (LIME) to explain the model. The results obtained an accuracy of 98.17% for the combination of vision transformer, random forest and contrast-limited adaptive histogram equalization and 99. 67% for the parallel model integration (ResNet101 and Xception). Based on these results, this paper proposed the deep learning approach—parallel model integration technique as the most effective method. Future work aims to extend the model to multi-class classification for tumor type detection and improve model generalization for broader applicability.
ISSN:2045-2322