Comprehensive molecular characterization of adult H3K27M mutated thalamic glioma long-term survivors

Comprehensive molecular characterization of adult H3K27M mutated thalamic glioma long-term survivors

Abstract H3K27-altered diffuse midline gliomas (H3-DMGs) represent aggressive tumors with fatal outcome and exceedingly rare cases have a long-term survival (LTS). We included 5 adult thalamic H3-DMG LTS and 13 short-term survivors (STS), and performed whole exome sequencing, RNA-seq and DNA methyla...

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Main Authors: Hao Xu, Xiaomu Hu, Biyun Wang, Ying Sun, Ye Wang, Qisheng Tang, Qiongji Zhu, Kun Song, Hong Chen, Lingchao Chen, Haixia Cheng, Zhiyong Qin
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Experimental Hematology & Oncology
Subjects:
H3K27-altered diffuse midline glioma
Long-term survivor
Mutation analysis
RNA sequencing
DNA methylation array
Online Access:https://doi.org/10.1186/s40164-025-00677-w
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