Color vision disturbances secondary to oral tranexamic acid
Abstract Tranexamic acid (TXA) is an antifibrinolytic commonly used to reduce blood loss due to surgical procedures, heavy menstruation, trauma, bleeding disorders, among other uses. Possible adverse reactions associated with TXA include abdominal pain, headache, fatigue, cerebral thrombosis, dizzin...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Journal of the American College of Emergency Physicians Open |
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| Online Access: | https://doi.org/10.1002/emp2.12456 |
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| author | Adam S. Kiser Gena L. Cooper Jonathan D. Napier Gavin T. Howington |
| author_facet | Adam S. Kiser Gena L. Cooper Jonathan D. Napier Gavin T. Howington |
| author_sort | Adam S. Kiser |
| collection | DOAJ |
| description | Abstract Tranexamic acid (TXA) is an antifibrinolytic commonly used to reduce blood loss due to surgical procedures, heavy menstruation, trauma, bleeding disorders, among other uses. Possible adverse reactions associated with TXA include abdominal pain, headache, fatigue, cerebral thrombosis, dizziness, retinal artery occlusion, chromatopsia, and more. We present a case of acute color vision disturbance developed soon after initiation of oral TXA for epistaxis prophylaxis in the setting of factor VII deficiency. To our knowledge we report the only case of color vision disturbance in a pediatric patient and the only case after receiving oral TXA. Soon after discontinuing oral TXA the patient's altered perception of color vision resolved. The patient was subsequently discharged home with a prescription for an alternative antifibrinolytic (aminocaproic acid) and follow‐up with neuro‐ophthalmology. |
| format | Article |
| id | doaj-art-7749a03b93f84b71bd3094e6b024d797 |
| institution | OA Journals |
| issn | 2688-1152 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the American College of Emergency Physicians Open |
| spelling | doaj-art-7749a03b93f84b71bd3094e6b024d7972025-08-20T01:51:23ZengElsevierJournal of the American College of Emergency Physicians Open2688-11522021-06-0123n/an/a10.1002/emp2.12456Color vision disturbances secondary to oral tranexamic acidAdam S. Kiser0Gena L. Cooper1Jonathan D. Napier2Gavin T. Howington3University of Kentucky College of Pharmacy Lexington Kentucky USADepartment of Emergency Medicine University of Kentucky HealthCare Lexington Kentucky USADepartment of Emergency Medicine University of Kentucky HealthCare Lexington Kentucky USADepartment of Pharmacy Practice and Science University of Kentucky College of Pharmacy Lexington Kentucky USAAbstract Tranexamic acid (TXA) is an antifibrinolytic commonly used to reduce blood loss due to surgical procedures, heavy menstruation, trauma, bleeding disorders, among other uses. Possible adverse reactions associated with TXA include abdominal pain, headache, fatigue, cerebral thrombosis, dizziness, retinal artery occlusion, chromatopsia, and more. We present a case of acute color vision disturbance developed soon after initiation of oral TXA for epistaxis prophylaxis in the setting of factor VII deficiency. To our knowledge we report the only case of color vision disturbance in a pediatric patient and the only case after receiving oral TXA. Soon after discontinuing oral TXA the patient's altered perception of color vision resolved. The patient was subsequently discharged home with a prescription for an alternative antifibrinolytic (aminocaproic acid) and follow‐up with neuro‐ophthalmology.https://doi.org/10.1002/emp2.12456antifibrinolyticfactor VII deficiencyocular pathologypediatrictranexamic acid |
| spellingShingle | Adam S. Kiser Gena L. Cooper Jonathan D. Napier Gavin T. Howington Color vision disturbances secondary to oral tranexamic acid Journal of the American College of Emergency Physicians Open antifibrinolytic factor VII deficiency ocular pathology pediatric tranexamic acid |
| title | Color vision disturbances secondary to oral tranexamic acid |
| title_full | Color vision disturbances secondary to oral tranexamic acid |
| title_fullStr | Color vision disturbances secondary to oral tranexamic acid |
| title_full_unstemmed | Color vision disturbances secondary to oral tranexamic acid |
| title_short | Color vision disturbances secondary to oral tranexamic acid |
| title_sort | color vision disturbances secondary to oral tranexamic acid |
| topic | antifibrinolytic factor VII deficiency ocular pathology pediatric tranexamic acid |
| url | https://doi.org/10.1002/emp2.12456 |
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