Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone
Abalone is an economically important mollusk, whose slow growth has impeded the recovery of its wild populations and development of aquaculture. The three-way cross hybrid abalone ((<i>Haliotis discus hannai</i>♀ × <i>H. fulgens</i>♂)♀ × <i>H. gigantea</i>♂, DF ×...
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2025-01-01
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| author | Qizhen Xiao Shihai Gong Zekun Huang Wenzhu Peng Zhaofang Han Yang Gan Yawei Shen Weiwei You Caihuan Ke Xuan Luo |
| author_facet | Qizhen Xiao Shihai Gong Zekun Huang Wenzhu Peng Zhaofang Han Yang Gan Yawei Shen Weiwei You Caihuan Ke Xuan Luo |
| author_sort | Qizhen Xiao |
| collection | DOAJ |
| description | Abalone is an economically important mollusk, whose slow growth has impeded the recovery of its wild populations and development of aquaculture. The three-way cross hybrid abalone ((<i>Haliotis discus hannai</i>♀ × <i>H. fulgens</i>♂)♀ × <i>H. gigantea</i>♂, DF × SS) demonstrated notable diversity in growth traits across the population with genetic differentiation, offering a model for exploring the molecular mechanisms of abalone growth. In this study, a total of 89 SNPs and 97 candidate genes were identified to be associated with growth-related traits of abalone using whole-genome resequencing and a genome-wide association study (GWAS) analysis. Then, ten overlap genes were found among these candidate genes by combining the results of GWAS and comparative transcriptomic analyses between the large individuals (L group) and small individuals (S group) of DF × SS. These overlap genes include up-regulated genes (<i>fabG</i>) and down-regulated genes (<i>HMCN1</i>, <i>TLR3</i>, <i>ITIH3</i>) between the L and the S groups, which are thought to function in growth in other organisms. The biological functions of these candidate genes in abalone still have to be confirmed, but they have improved our understanding of the molecular mechanisms behind abalone growth traits and provided molecular markers for abalone breeding programs. |
| format | Article |
| id | doaj-art-77490303f05440ebae7b80117e6512fb |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Animals |
| spelling | doaj-art-77490303f05440ebae7b80117e6512fb2025-01-24T13:18:06ZengMDPI AGAnimals2076-26152025-01-0115221110.3390/ani15020211Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid AbaloneQizhen Xiao0Shihai Gong1Zekun Huang2Wenzhu Peng3Zhaofang Han4Yang Gan5Yawei Shen6Weiwei You7Caihuan Ke8Xuan Luo9Fujian Provincial Key Lab of Coastal Basin Environment, Fujian Polytechnic Normal University, Fuqing 350300, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, ChinaAbalone is an economically important mollusk, whose slow growth has impeded the recovery of its wild populations and development of aquaculture. The three-way cross hybrid abalone ((<i>Haliotis discus hannai</i>♀ × <i>H. fulgens</i>♂)♀ × <i>H. gigantea</i>♂, DF × SS) demonstrated notable diversity in growth traits across the population with genetic differentiation, offering a model for exploring the molecular mechanisms of abalone growth. In this study, a total of 89 SNPs and 97 candidate genes were identified to be associated with growth-related traits of abalone using whole-genome resequencing and a genome-wide association study (GWAS) analysis. Then, ten overlap genes were found among these candidate genes by combining the results of GWAS and comparative transcriptomic analyses between the large individuals (L group) and small individuals (S group) of DF × SS. These overlap genes include up-regulated genes (<i>fabG</i>) and down-regulated genes (<i>HMCN1</i>, <i>TLR3</i>, <i>ITIH3</i>) between the L and the S groups, which are thought to function in growth in other organisms. The biological functions of these candidate genes in abalone still have to be confirmed, but they have improved our understanding of the molecular mechanisms behind abalone growth traits and provided molecular markers for abalone breeding programs.https://www.mdpi.com/2076-2615/15/2/211three-way crossabaloneGWAStranscriptomegrowth |
| spellingShingle | Qizhen Xiao Shihai Gong Zekun Huang Wenzhu Peng Zhaofang Han Yang Gan Yawei Shen Weiwei You Caihuan Ke Xuan Luo Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone Animals three-way cross abalone GWAS transcriptome growth |
| title | Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone |
| title_full | Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone |
| title_fullStr | Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone |
| title_full_unstemmed | Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone |
| title_short | Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone |
| title_sort | ten candidate genes were identified to be associated with the great growth differentiation in the three way cross hybrid abalone |
| topic | three-way cross abalone GWAS transcriptome growth |
| url | https://www.mdpi.com/2076-2615/15/2/211 |
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