A Review of the Knops Blood Group System
The Knops blood group system is an independent blood group system recognized by International Society of Blood Transfusion (ISBT) in 1992, and latest time consisting of 13 antigens carried on a glycoprotein of 2489 amino acids and called the Complement C3b/C4b Receptor 1 (CR1). Erythrocyte KN antige...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296241309638 |
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| author | Xiaohui Ma MD Zhen Zhao MD Yan Zhang MD Lingbo Li MD Jing Zhong MD |
| author_facet | Xiaohui Ma MD Zhen Zhao MD Yan Zhang MD Lingbo Li MD Jing Zhong MD |
| author_sort | Xiaohui Ma MD |
| collection | DOAJ |
| description | The Knops blood group system is an independent blood group system recognized by International Society of Blood Transfusion (ISBT) in 1992, and latest time consisting of 13 antigens carried on a glycoprotein of 2489 amino acids and called the Complement C3b/C4b Receptor 1 (CR1). Erythrocyte KN antigen was first reported in 1970, and CR1 is a protein coding gene that is a member of the receptors of complement activation (RCA) family and is located in the “cluster RCA” region of chromosome 1. CR1 is an important participant in the erythrocyte immune machinery and plays an major role in inhibiting complement activation, and polymorphisms in its expression have been closely associated with a variety of diseases, including systemic lupus erythematosus (SLE), malaria, Plasmodium falciparum malaria, Alzheimer's disease (AD) and leprosy. Antibodies to the Knops system usually do not bind to complement and do not cause a hemolytic reaction. However, anti-Knops antibodies can be detected in the serum of some pregnant women. Generally, however, they only test positive by direct antiglobulin test (DAT) and most of them do not cause hemolytic disease of the newborn (HDN). This article is a review of the progress of the Knops blood group system. |
| format | Article |
| id | doaj-art-7747264aaa054e839005ac7a6509eae4 |
| institution | OA Journals |
| issn | 1938-2723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-7747264aaa054e839005ac7a6509eae42025-08-20T02:32:21ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232024-12-013010.1177/10760296241309638A Review of the Knops Blood Group SystemXiaohui Ma MD0Zhen Zhao MD1Yan Zhang MD2Lingbo Li MD3Jing Zhong MD4 Cancer Center, , Changchun, China Department of Blood Transfusion, , Changchun, China Changchun Bioxun Biotechnology Limited Liability Company, Changchun, China Tianjin Dexiang Biotechnology Co., Ltd, Tianjin, China Department of Blood Transfusion, , Shaoyang, ChinaThe Knops blood group system is an independent blood group system recognized by International Society of Blood Transfusion (ISBT) in 1992, and latest time consisting of 13 antigens carried on a glycoprotein of 2489 amino acids and called the Complement C3b/C4b Receptor 1 (CR1). Erythrocyte KN antigen was first reported in 1970, and CR1 is a protein coding gene that is a member of the receptors of complement activation (RCA) family and is located in the “cluster RCA” region of chromosome 1. CR1 is an important participant in the erythrocyte immune machinery and plays an major role in inhibiting complement activation, and polymorphisms in its expression have been closely associated with a variety of diseases, including systemic lupus erythematosus (SLE), malaria, Plasmodium falciparum malaria, Alzheimer's disease (AD) and leprosy. Antibodies to the Knops system usually do not bind to complement and do not cause a hemolytic reaction. However, anti-Knops antibodies can be detected in the serum of some pregnant women. Generally, however, they only test positive by direct antiglobulin test (DAT) and most of them do not cause hemolytic disease of the newborn (HDN). This article is a review of the progress of the Knops blood group system.https://doi.org/10.1177/10760296241309638 |
| spellingShingle | Xiaohui Ma MD Zhen Zhao MD Yan Zhang MD Lingbo Li MD Jing Zhong MD A Review of the Knops Blood Group System Clinical and Applied Thrombosis/Hemostasis |
| title | A Review of the Knops Blood Group
System |
| title_full | A Review of the Knops Blood Group
System |
| title_fullStr | A Review of the Knops Blood Group
System |
| title_full_unstemmed | A Review of the Knops Blood Group
System |
| title_short | A Review of the Knops Blood Group
System |
| title_sort | review of the knops blood group system |
| url | https://doi.org/10.1177/10760296241309638 |
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