ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL?
Mechanisms of atherothrombosis in atherosclerosis of coronary arteries are described. Mechanism of action and clinical efficiency of antithrombotic and antiplatelet medicines such as acetylsalicylic acid, warfarin, ticlopidine and clopidogrel are discussed. Study data on new antiplatelet drugs are g...
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1031 |
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| author | I. A. Latfullin A. A. Podolskaya |
| author_facet | I. A. Latfullin A. A. Podolskaya |
| author_sort | I. A. Latfullin |
| collection | DOAJ |
| description | Mechanisms of atherothrombosis in atherosclerosis of coronary arteries are described. Mechanism of action and clinical efficiency of antithrombotic and antiplatelet medicines such as acetylsalicylic acid, warfarin, ticlopidine and clopidogrel are discussed. Study data on new antiplatelet drugs are given: selective thromboxane inhibitors, antagonists of thromboxane receptors, blockers of platelet receptors for glycoproteins GPIIb/IIIa. Possibility of clinical use of additional antiplatelet features of statines is discussed, as well as their connection to stimulation of nitrate oxide production, powerful endogenous antiplatelet factor. Examples of other donators of nitrate oxide and activators of its endogenous synthesis are given. |
| format | Article |
| id | doaj-art-7742cd57cc4e4649af53df240dc25b1e |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-7742cd57cc4e4649af53df240dc25b1e2025-08-23T10:00:25ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0123374510.20996/1819-6446-2006-2-3-37-451030ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL?I. A. Latfullin0A. A. Podolskaya1Kazan State Medical UniversityKazan State Medical UniversityMechanisms of atherothrombosis in atherosclerosis of coronary arteries are described. Mechanism of action and clinical efficiency of antithrombotic and antiplatelet medicines such as acetylsalicylic acid, warfarin, ticlopidine and clopidogrel are discussed. Study data on new antiplatelet drugs are given: selective thromboxane inhibitors, antagonists of thromboxane receptors, blockers of platelet receptors for glycoproteins GPIIb/IIIa. Possibility of clinical use of additional antiplatelet features of statines is discussed, as well as their connection to stimulation of nitrate oxide production, powerful endogenous antiplatelet factor. Examples of other donators of nitrate oxide and activators of its endogenous synthesis are given.https://www.rpcardio.online/jour/article/view/1031atherothrombosisantithrombocyte meansacetylsalicylic acidticlopidineclopidogrelwarfarinreceptors of glycoproteins gpiib/iiiastatinsnitrate oxid |
| spellingShingle | I. A. Latfullin A. A. Podolskaya ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL? Рациональная фармакотерапия в кардиологии atherothrombosis antithrombocyte means acetylsalicylic acid ticlopidine clopidogrel warfarin receptors of glycoproteins gpiib/iiia statins nitrate oxid |
| title | ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL? |
| title_full | ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL? |
| title_fullStr | ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL? |
| title_full_unstemmed | ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL? |
| title_short | ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL? |
| title_sort | antithrombotic therapy of ischemic heart disease from fast acting antiaggregants to statines and nitrate oxide is it real |
| topic | atherothrombosis antithrombocyte means acetylsalicylic acid ticlopidine clopidogrel warfarin receptors of glycoproteins gpiib/iiia statins nitrate oxid |
| url | https://www.rpcardio.online/jour/article/view/1031 |
| work_keys_str_mv | AT ialatfullin antithrombotictherapyofischemicheartdiseasefromfastactingantiaggregantstostatinesandnitrateoxideisitreal AT aapodolskaya antithrombotictherapyofischemicheartdiseasefromfastactingantiaggregantstostatinesandnitrateoxideisitreal |