Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib
Drug-induced liver injury (DILI) is a common clinical entity but is underreported due to various reasons. Cyclooxygenase-2 inhibitors like Celecoxib have been proven to be associated with lesser incidence of adverse drug reactions compared to other nonsteroidal anti-inflammatory drugs (NSAID). Howev...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/315479 |
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| author | Suresh Kumar Nayudu Shanti Badipatla Masooma Niazi Bhavna Balar |
| author_facet | Suresh Kumar Nayudu Shanti Badipatla Masooma Niazi Bhavna Balar |
| author_sort | Suresh Kumar Nayudu |
| collection | DOAJ |
| description | Drug-induced liver injury (DILI) is a common clinical entity but is underreported due to various reasons. Cyclooxygenase-2 inhibitors like Celecoxib have been proven to be associated with lesser incidence of adverse drug reactions compared to other nonsteroidal anti-inflammatory drugs (NSAID). However, Celecoxib has been rarely reported to be associated with cholestasis and hepatitis. We present a young Hispanic female presented with cholestatic liver chemistries who has been taking Celecoxib for 3 weeks. Extensive workup did not support diagnosis of viral, autoimmune, or metabolic liver diseases. Liver biopsy revealed findings suggestive of secondary sclerosing cholangitis. Imaging studies were negative for large duct involvement, and endoscopy ruled out inflammatory bowel disease. Liver chemistries normalized after cessation of medication. We recommend that physician should be aware of this rare complication when prescribing Celecoxib. |
| format | Article |
| id | doaj-art-773f499fdcc147ec805a5c98b5209718 |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-773f499fdcc147ec805a5c98b52097182025-08-20T02:07:34ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/315479315479Cholestatic Hepatitis with Small Duct Injury Associated with CelecoxibSuresh Kumar Nayudu0Shanti Badipatla1Masooma Niazi2Bhavna Balar3Division of Gastroenterology and Hepatology, Bronx Lebanon Hospital Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10457, USADepartment of Medicine, Bronx Lebanon Hospital Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10457, USADepartment of Pathology, Bronx Lebanon Hospital Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10457, USADivision of Gastroenterology and Hepatology, Bronx Lebanon Hospital Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10457, USADrug-induced liver injury (DILI) is a common clinical entity but is underreported due to various reasons. Cyclooxygenase-2 inhibitors like Celecoxib have been proven to be associated with lesser incidence of adverse drug reactions compared to other nonsteroidal anti-inflammatory drugs (NSAID). However, Celecoxib has been rarely reported to be associated with cholestasis and hepatitis. We present a young Hispanic female presented with cholestatic liver chemistries who has been taking Celecoxib for 3 weeks. Extensive workup did not support diagnosis of viral, autoimmune, or metabolic liver diseases. Liver biopsy revealed findings suggestive of secondary sclerosing cholangitis. Imaging studies were negative for large duct involvement, and endoscopy ruled out inflammatory bowel disease. Liver chemistries normalized after cessation of medication. We recommend that physician should be aware of this rare complication when prescribing Celecoxib.http://dx.doi.org/10.1155/2013/315479 |
| spellingShingle | Suresh Kumar Nayudu Shanti Badipatla Masooma Niazi Bhavna Balar Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib Case Reports in Medicine |
| title | Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib |
| title_full | Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib |
| title_fullStr | Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib |
| title_full_unstemmed | Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib |
| title_short | Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib |
| title_sort | cholestatic hepatitis with small duct injury associated with celecoxib |
| url | http://dx.doi.org/10.1155/2013/315479 |
| work_keys_str_mv | AT sureshkumarnayudu cholestatichepatitiswithsmallductinjuryassociatedwithcelecoxib AT shantibadipatla cholestatichepatitiswithsmallductinjuryassociatedwithcelecoxib AT masoomaniazi cholestatichepatitiswithsmallductinjuryassociatedwithcelecoxib AT bhavnabalar cholestatichepatitiswithsmallductinjuryassociatedwithcelecoxib |