Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis
Xixi Xiao,1 Guoquan Huang,2,3 Xinqiao Yu,2 Yong Tan2,3 1The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Minzu University, Enshi, 445000, People’s Republic of China; 2Hubei Selenium and Human Health Institute, The Central Hospital of Enshi Tujia and Miao Autonomous Prefectur...
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Dove Medical Press
2025-01-01
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| author | Xiao X Huang G Yu X Tan Y |
| author_facet | Xiao X Huang G Yu X Tan Y |
| author_sort | Xiao X |
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| description | Xixi Xiao,1 Guoquan Huang,2,3 Xinqiao Yu,2 Yong Tan2,3 1The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Minzu University, Enshi, 445000, People’s Republic of China; 2Hubei Selenium and Human Health Institute, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, 445000, People’s Republic of China; 3Hubei Provincial Key Laboratory of Selenium Resources and Bioapplications, Enshi, 445000, People’s Republic of ChinaCorrespondence: Xinqiao Yu; Yong Tan, Email 1361095717@qq.com; tanyong951018@163.comAbstract: Selenium (Se), a critically essential trace element, plays a crucial role in diverse physiological processes within the human body, such as oxidative stress response, inflammation regulation, apoptosis, and lipid metabolism. Organ fibrosis, a pathological condition caused by various factors, has become a significant global health issue. Numerous studies have demonstrated the substantial impact of Se on fibrotic diseases. This review delves into the latest research advancements in Se and Se-related biological agents for alleviating fibrosis in the heart, liver, lungs, and kidneys, detailing their mechanisms of action within fibrotic pathways. Additionally, the article summa-rizes some of the anti-fibrotic drugs currently in clinical trials for the aforementioned organ fibroses.Keywords: selenium, fibrosis, organ, clinical |
| format | Article |
| id | doaj-art-773ccb1b61794597b63705bfc41cac66 |
| institution | Kabale University |
| issn | 1177-8881 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Drug Design, Development and Therapy |
| spelling | doaj-art-773ccb1b61794597b63705bfc41cac662025-01-14T16:51:43ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-01-01Volume 1925126599242Advances in Selenium and Related Compounds Inhibiting Multi-Organ FibrosisXiao XHuang GYu XTan YXixi Xiao,1 Guoquan Huang,2,3 Xinqiao Yu,2 Yong Tan2,3 1The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Minzu University, Enshi, 445000, People’s Republic of China; 2Hubei Selenium and Human Health Institute, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, 445000, People’s Republic of China; 3Hubei Provincial Key Laboratory of Selenium Resources and Bioapplications, Enshi, 445000, People’s Republic of ChinaCorrespondence: Xinqiao Yu; Yong Tan, Email 1361095717@qq.com; tanyong951018@163.comAbstract: Selenium (Se), a critically essential trace element, plays a crucial role in diverse physiological processes within the human body, such as oxidative stress response, inflammation regulation, apoptosis, and lipid metabolism. Organ fibrosis, a pathological condition caused by various factors, has become a significant global health issue. Numerous studies have demonstrated the substantial impact of Se on fibrotic diseases. This review delves into the latest research advancements in Se and Se-related biological agents for alleviating fibrosis in the heart, liver, lungs, and kidneys, detailing their mechanisms of action within fibrotic pathways. Additionally, the article summa-rizes some of the anti-fibrotic drugs currently in clinical trials for the aforementioned organ fibroses.Keywords: selenium, fibrosis, organ, clinicalhttps://www.dovepress.com/advances-in-selenium-and-related-compounds-inhibiting-multi-organ-fibr-peer-reviewed-fulltext-article-DDDTseleniumfibrosisorganclinical |
| spellingShingle | Xiao X Huang G Yu X Tan Y Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis Drug Design, Development and Therapy selenium fibrosis organ clinical |
| title | Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis |
| title_full | Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis |
| title_fullStr | Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis |
| title_full_unstemmed | Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis |
| title_short | Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis |
| title_sort | advances in selenium and related compounds inhibiting multi organ fibrosis |
| topic | selenium fibrosis organ clinical |
| url | https://www.dovepress.com/advances-in-selenium-and-related-compounds-inhibiting-multi-organ-fibr-peer-reviewed-fulltext-article-DDDT |
| work_keys_str_mv | AT xiaox advancesinseleniumandrelatedcompoundsinhibitingmultiorganfibrosis AT huangg advancesinseleniumandrelatedcompoundsinhibitingmultiorganfibrosis AT yux advancesinseleniumandrelatedcompoundsinhibitingmultiorganfibrosis AT tany advancesinseleniumandrelatedcompoundsinhibitingmultiorganfibrosis |