Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study
ABSTRACT Background This study mainly explores the correlation between prognostic nutritional index (PNI) and systemic immune inflammatory index (SII) and sudden sensorineural hearing loss (SSNHL). Methods In this study, 150 SSNHL patients (average age 48.98 ± 16.45 years; 48.92% male, 50.93% female...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70217 |
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| author | Xu Zhang Junyi Wu Wentao Zhang Maohua Wang Bing Guan Qiao Jiang Chunping Yang |
| author_facet | Xu Zhang Junyi Wu Wentao Zhang Maohua Wang Bing Guan Qiao Jiang Chunping Yang |
| author_sort | Xu Zhang |
| collection | DOAJ |
| description | ABSTRACT Background This study mainly explores the correlation between prognostic nutritional index (PNI) and systemic immune inflammatory index (SII) and sudden sensorineural hearing loss (SSNHL). Methods In this study, 150 SSNHL patients (average age 48.98 ± 16.45 years; 48.92% male, 50.93% female) were categorized into effective and ineffective treatment groups. Additionally, 150 healthy volunteers (average age 49.49 ± 9.75 years; 51.08% male, 49.07% female) served as the control group. Baseline characteristics, clinical data, and laboratory results were collected, and SII and PNI were calculated for analysis. Linear correlation, logistic regression, and receiver characteristic curve analyses were conducted to explore the link between immune nutrition levels and SSNHL. Results In the SSNHL group, PNI was significantly lower, while SII, platelet, and neutrophil counts were notably higher compared to controls (p < 0.001). Logistic regression identified low PNI (OR = 0.878), high SII (OR = 1.005), and elevated neutrophils (OR = 1.758) as predictors of SSNHL. Data comparison showed higher nutritional levels in the effective treatment group than in the ineffective group. Logistic regression indicated that low PNI (OR = 1.075) and high SII (OR = 1.004) were strongly linked to treatment outcomes. Conclusion There is a relationship between the body's immune nutrition level and the occurrence and development of SSNHL. Lower PNI and higher SII are associated with the occurrence of SSNHL and poor outcomes. However, further research into the underlying mechanisms is needed. |
| format | Article |
| id | doaj-art-773b20b6351c43fea4e17ae254663b3e |
| institution | Kabale University |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-773b20b6351c43fea4e17ae254663b3e2025-08-20T03:28:00ZengWileyImmunity, Inflammation and Disease2050-45272025-06-01136n/an/a10.1002/iid3.70217Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort StudyXu Zhang0Junyi Wu1Wentao Zhang2Maohua Wang3Bing Guan4Qiao Jiang5Chunping Yang6Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaDepartment of Otolaryngology‐Head and Neck Surgery Northern Jiangsu People's Hospital Affiliated to Yangzhou University Yangzhou Jiangsu ChinaDepartment of Otolaryngology, Head and Neck Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaDepartment of Otolaryngology, Head and Neck Surgery The First People's Hospital of Foshan, Hearing and Balance Medical Engineering Technology Center of Guangdong Foshan Guangdong ChinaDepartment of Otolaryngology‐Head and Neck Surgery Northern Jiangsu People's Hospital Affiliated to Yangzhou University Yangzhou Jiangsu ChinaDepartment of Neurology Deyang Fifth Hospital Deyang Sichuan ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaABSTRACT Background This study mainly explores the correlation between prognostic nutritional index (PNI) and systemic immune inflammatory index (SII) and sudden sensorineural hearing loss (SSNHL). Methods In this study, 150 SSNHL patients (average age 48.98 ± 16.45 years; 48.92% male, 50.93% female) were categorized into effective and ineffective treatment groups. Additionally, 150 healthy volunteers (average age 49.49 ± 9.75 years; 51.08% male, 49.07% female) served as the control group. Baseline characteristics, clinical data, and laboratory results were collected, and SII and PNI were calculated for analysis. Linear correlation, logistic regression, and receiver characteristic curve analyses were conducted to explore the link between immune nutrition levels and SSNHL. Results In the SSNHL group, PNI was significantly lower, while SII, platelet, and neutrophil counts were notably higher compared to controls (p < 0.001). Logistic regression identified low PNI (OR = 0.878), high SII (OR = 1.005), and elevated neutrophils (OR = 1.758) as predictors of SSNHL. Data comparison showed higher nutritional levels in the effective treatment group than in the ineffective group. Logistic regression indicated that low PNI (OR = 1.075) and high SII (OR = 1.004) were strongly linked to treatment outcomes. Conclusion There is a relationship between the body's immune nutrition level and the occurrence and development of SSNHL. Lower PNI and higher SII are associated with the occurrence of SSNHL and poor outcomes. However, further research into the underlying mechanisms is needed.https://doi.org/10.1002/iid3.70217immune nutritional levelprognostic nutritional indexsudden sensorineural hearing losssystemic immune inflammatory index |
| spellingShingle | Xu Zhang Junyi Wu Wentao Zhang Maohua Wang Bing Guan Qiao Jiang Chunping Yang Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study Immunity, Inflammation and Disease immune nutritional level prognostic nutritional index sudden sensorineural hearing loss systemic immune inflammatory index |
| title | Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study |
| title_full | Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study |
| title_fullStr | Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study |
| title_full_unstemmed | Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study |
| title_short | Utility of Prognostic Nutritional Index and Systemic Immune‐Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study |
| title_sort | utility of prognostic nutritional index and systemic immune inflammation index inpatients with sudden sensorineural hearing loss a large prospective cohort study |
| topic | immune nutritional level prognostic nutritional index sudden sensorineural hearing loss systemic immune inflammatory index |
| url | https://doi.org/10.1002/iid3.70217 |
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