The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment
Background/Aim. Autogenous bone grafting has been the gold standard in clinical cases when bone grafts are required for bone defects in dentistry. The study was undertaken to evaluate multilevel designed carbonated hydroxyapatite (CHA) obtained by hydrothermal method, as a bone substitute i...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501405462M.pdf |
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| author | Marković Dejan Jokanović Vukoman Petrović Bojan Perić Tamara Vukomanović Biserka |
| author_facet | Marković Dejan Jokanović Vukoman Petrović Bojan Perić Tamara Vukomanović Biserka |
| author_sort | Marković Dejan |
| collection | DOAJ |
| description | Background/Aim. Autogenous bone grafting has been the gold standard in
clinical cases when bone grafts are required for bone defects in dentistry.
The study was undertaken to evaluate multilevel designed carbonated
hydroxyapatite (CHA) obtained by hydrothermal method, as a bone substitute in
healing bone defects with or without corticosteroid treatment in rats as
assessed by histopathologic methods. Methods. Bone defects were created in
the alveolar bone by teeth extraction in 12 rats. The animals were initially
divided into two groups. The experimental group was pretreated with
corticosteroids: methylprednisolone and dexamethasone, intramuscularly, while
the control group was without therapy. Posterior teeth extraction had been
performed after the corticosteroid therapy. The extraction defects were
fulfilled with hydroxyapatite with bimodal particle sizes in the range of
50-250 μm and the sample from postextocactional defect of the alveolar bone
was analyzed pathohystologically. Results. The histopatological
investigations confirmed the biologic properties of the applied material. The
evident growth of new bone in the alveolar ridge was clearly noticed in both
groups of rats. Carbonated HA obtained by hydrothermal method promoted bone
formation in the preformed defects, confirming its efficacy for usage in bone
defects. Complete resorption of the material’s particles took place after 25
weeks. Conclusion. Hydroxyapatite completely meets the clinical requirements
for a bone substitute material. Due to its microstructure, complete
resorption took place during the observation period of the study.
Corticosteroid treatment did not significantly affect new bone formation in
the region of postextractional defects. [Projekat Ministarstva nauke
Republike Srbije, br. 172026] |
| format | Article |
| id | doaj-art-7736ba73dce14a6ca4e81bd9c61375ec |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-7736ba73dce14a6ca4e81bd9c61375ec2025-08-20T01:57:55ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502014-01-0171546246610.2298/VSP1405462M0042-84501405462MThe efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatmentMarković Dejan0Jokanović Vukoman1Petrović Bojan2Perić Tamara3Vukomanović Biserka4Faculty of Dentistry, BelgradeInstitute of Nuclear Sciences Vinča, Laboratory for Radiation Chemistry and Physics, BelgradeFaculty of Medicine, Dentistry Clinic of Vojvodina, Novi SadFaculty of Dentistry, BelgradeMilitary Medical Academy, Institute of Pathology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeBackground/Aim. Autogenous bone grafting has been the gold standard in clinical cases when bone grafts are required for bone defects in dentistry. The study was undertaken to evaluate multilevel designed carbonated hydroxyapatite (CHA) obtained by hydrothermal method, as a bone substitute in healing bone defects with or without corticosteroid treatment in rats as assessed by histopathologic methods. Methods. Bone defects were created in the alveolar bone by teeth extraction in 12 rats. The animals were initially divided into two groups. The experimental group was pretreated with corticosteroids: methylprednisolone and dexamethasone, intramuscularly, while the control group was without therapy. Posterior teeth extraction had been performed after the corticosteroid therapy. The extraction defects were fulfilled with hydroxyapatite with bimodal particle sizes in the range of 50-250 μm and the sample from postextocactional defect of the alveolar bone was analyzed pathohystologically. Results. The histopatological investigations confirmed the biologic properties of the applied material. The evident growth of new bone in the alveolar ridge was clearly noticed in both groups of rats. Carbonated HA obtained by hydrothermal method promoted bone formation in the preformed defects, confirming its efficacy for usage in bone defects. Complete resorption of the material’s particles took place after 25 weeks. Conclusion. Hydroxyapatite completely meets the clinical requirements for a bone substitute material. Due to its microstructure, complete resorption took place during the observation period of the study. Corticosteroid treatment did not significantly affect new bone formation in the region of postextractional defects. [Projekat Ministarstva nauke Republike Srbije, br. 172026]http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501405462M.pdftooth extractionalveolar bone losstransplantsratsdurapatiteadrenal cortex hormones |
| spellingShingle | Marković Dejan Jokanović Vukoman Petrović Bojan Perić Tamara Vukomanović Biserka The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment Vojnosanitetski Pregled tooth extraction alveolar bone loss transplants rats durapatite adrenal cortex hormones |
| title | The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment |
| title_full | The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment |
| title_fullStr | The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment |
| title_full_unstemmed | The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment |
| title_short | The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment |
| title_sort | efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment |
| topic | tooth extraction alveolar bone loss transplants rats durapatite adrenal cortex hormones |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501405462M.pdf |
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