Metabolism and Immune Suppressive Response in Liver Cancer
Hepatocellular carcinoma (HCC) constitutes more than 90% of the primary tumor of the liver. Metabolic reprogramming is decisive in promoting HCC development. The new metabolic program drives the surrounding immune cells to an immune suppressive commitment, enabling tumor survival. The enhanced metab...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/6/1461 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849435271545749504 |
|---|---|
| author | Patrizio Caini Vinicio Carloni |
| author_facet | Patrizio Caini Vinicio Carloni |
| author_sort | Patrizio Caini |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) constitutes more than 90% of the primary tumor of the liver. Metabolic reprogramming is decisive in promoting HCC development. The new metabolic program drives the surrounding immune cells to an immune suppressive commitment, enabling tumor survival. The enhanced metabolic activity of cancer cells leads to competition for essential nutrients, depriving non-malignant cells of critical resources. Simultaneously, the accumulation of metabolic byproducts within the tumor microenvironment (TME) selectively favors innate immune responses while impairing adaptive immunity. Recent advances in cancer immunotherapy underscore the importance of targeting both immune cell function and metabolic pathways. In this context, reprogramming the metabolism of effector and regulatory immune cells represents a promising therapeutic avenue. This review focuses on a relatively underexplored aspect of liver cancer immunology, the immunosuppressive role of tumor-associated macrophages (TAMs) and regulatory T cells (Tregs) driven by metabolic alterations and how these mechanisms contribute to the suppression of effective anti-tumor immune responses. |
| format | Article |
| id | doaj-art-7735e0e2b64f4a2ca2b445168355c846 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-7735e0e2b64f4a2ca2b445168355c8462025-08-20T03:26:21ZengMDPI AGBiomedicines2227-90592025-06-01136146110.3390/biomedicines13061461Metabolism and Immune Suppressive Response in Liver CancerPatrizio Caini0Vinicio Carloni1Department of Experimental and Clinical Medicine, University of Florence, 50121 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50121 Florence, ItalyHepatocellular carcinoma (HCC) constitutes more than 90% of the primary tumor of the liver. Metabolic reprogramming is decisive in promoting HCC development. The new metabolic program drives the surrounding immune cells to an immune suppressive commitment, enabling tumor survival. The enhanced metabolic activity of cancer cells leads to competition for essential nutrients, depriving non-malignant cells of critical resources. Simultaneously, the accumulation of metabolic byproducts within the tumor microenvironment (TME) selectively favors innate immune responses while impairing adaptive immunity. Recent advances in cancer immunotherapy underscore the importance of targeting both immune cell function and metabolic pathways. In this context, reprogramming the metabolism of effector and regulatory immune cells represents a promising therapeutic avenue. This review focuses on a relatively underexplored aspect of liver cancer immunology, the immunosuppressive role of tumor-associated macrophages (TAMs) and regulatory T cells (Tregs) driven by metabolic alterations and how these mechanisms contribute to the suppression of effective anti-tumor immune responses.https://www.mdpi.com/2227-9059/13/6/1461glycolysishypoxiamacrophagesregulatory T cellsepigenetics |
| spellingShingle | Patrizio Caini Vinicio Carloni Metabolism and Immune Suppressive Response in Liver Cancer Biomedicines glycolysis hypoxia macrophages regulatory T cells epigenetics |
| title | Metabolism and Immune Suppressive Response in Liver Cancer |
| title_full | Metabolism and Immune Suppressive Response in Liver Cancer |
| title_fullStr | Metabolism and Immune Suppressive Response in Liver Cancer |
| title_full_unstemmed | Metabolism and Immune Suppressive Response in Liver Cancer |
| title_short | Metabolism and Immune Suppressive Response in Liver Cancer |
| title_sort | metabolism and immune suppressive response in liver cancer |
| topic | glycolysis hypoxia macrophages regulatory T cells epigenetics |
| url | https://www.mdpi.com/2227-9059/13/6/1461 |
| work_keys_str_mv | AT patriziocaini metabolismandimmunesuppressiveresponseinlivercancer AT viniciocarloni metabolismandimmunesuppressiveresponseinlivercancer |