Evaluating miscarriage incidence after COVID-19 vaccination
Abstract COVID-19 infection during pregnancy might be associated with maternal complications. This study aimed to investigate the impact of COVID-19 vaccination on the risk of miscarriage. This cohort study included 26,701 women of reproductive age (15–49) who were vaccinated with different vaccines...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-06904-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238695277756416 |
|---|---|
| author | Fariba Shahraki-Sanavi Sajad Sahab-Negah Sairan Nili Parvin Mangolian shahrbabaki Alireza Ansari-moghaddam Mohammad Fereidouni Abtin Heidarzadeh Mostafa Enayatrad Sepideh Mahdavi Roqayeh Aliyari Mansooreh Fateh Hamidreza Khajeha Zahra Emamian Elahe Behmanesh Hossein Sheibani Maryam Abbaszadeh Reza Jafari Maryam Valikhani Ehsan Binesh Hamid Vahedi Sahar Shabestari Reza Chaman Hamid Sharifi Mohammad Hassan Emamian |
| author_facet | Fariba Shahraki-Sanavi Sajad Sahab-Negah Sairan Nili Parvin Mangolian shahrbabaki Alireza Ansari-moghaddam Mohammad Fereidouni Abtin Heidarzadeh Mostafa Enayatrad Sepideh Mahdavi Roqayeh Aliyari Mansooreh Fateh Hamidreza Khajeha Zahra Emamian Elahe Behmanesh Hossein Sheibani Maryam Abbaszadeh Reza Jafari Maryam Valikhani Ehsan Binesh Hamid Vahedi Sahar Shabestari Reza Chaman Hamid Sharifi Mohammad Hassan Emamian |
| author_sort | Fariba Shahraki-Sanavi |
| collection | DOAJ |
| description | Abstract COVID-19 infection during pregnancy might be associated with maternal complications. This study aimed to investigate the impact of COVID-19 vaccination on the risk of miscarriage. This cohort study included 26,701 women of reproductive age (15–49) who were vaccinated with different vaccines (Sinopharm, Sputnik V, AZD1222 and CoVIran Barekat) between April 2021 and August 2022 in seven cities in Iran. Among them 459 women were pregnant and included in this analysis. All pregnant women were followed up until the end of their pregnancy. The mean age (standard deviation) of pregnant women was 31.7 (6.8) years. Among them, 50 miscarriage cases occurred. The cumulative incidence of miscarriage was 10.9%; 95% confidence intervals [CI] 8.0–13.8) in total, and 11.0% (5.9–16.1), 9.7% (4.4–14.9), 12.0% (5.9–18.2), and 11.1% (4.2–18.0) for AZD1222, Sputnik V, Sinopharm and Barekat vaccines respectively. Cumulative incidence rates by vaccine brands were not statistically significant (P value = 0.962). The mean (SD) time interval between conception and vaccination was 3.5 (3.8) weeks and it was 7.5 (2.7) weeks for the age of the fetus at miscarriage. In general, the miscarriage rate in women of reproductive age was 4.8 (95% CI 4.1–5.7) per 1000 women. The estimated incidence rates were not higher than expected; therefore, it can be argued that COVID − 19 vaccination with Sputnik V, Sinopharm, Barekat and AZD1222 does not increase the probability of miscarriage and the vaccines are therefore safe in this respect. |
| format | Article |
| id | doaj-art-77350fbe2b0845a2a458608bbd7f72be |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-77350fbe2b0845a2a458608bbd7f72be2025-08-20T04:01:25ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-06904-yEvaluating miscarriage incidence after COVID-19 vaccinationFariba Shahraki-Sanavi0Sajad Sahab-Negah1Sairan Nili2Parvin Mangolian shahrbabaki3Alireza Ansari-moghaddam4Mohammad Fereidouni5Abtin Heidarzadeh6Mostafa Enayatrad7Sepideh Mahdavi8Roqayeh Aliyari9Mansooreh Fateh10Hamidreza Khajeha11Zahra Emamian12Elahe Behmanesh13Hossein Sheibani14Maryam Abbaszadeh15Reza Jafari16Maryam Valikhani17Ehsan Binesh18Hamid Vahedi19Sahar Shabestari20Reza Chaman21Hamid Sharifi22Mohammad Hassan Emamian23Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical SciencesMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical SciencesSocial Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical SciencesNursing Research Center, Razi Faculty of Nursing and Midwifery, Department of Critical Care, Kerman University of Medical SciencesHealth Promotion Research Center, Zahedan University of Medical SciencesCellular and Molecular Research Center, Birjand University of Medical SciencesSchool of Medicine, Guilan University of Medical SciencesClinical Research Development Unit, Bahar Hospital, Shahroud University of Medical ScienceDepartment of Epidemiology, School of Public Health, Shahroud University of Medical SciencesCenter for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical SciencesCenter for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical SciencesOphthalmic Epidemiology Research Center, Shahroud University of Medical SciencesHealth Technology Incubator Center, Shahroud University of Medical SciencesHealth Technology Incubator Center, Shahroud University of Medical SciencesClinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical ScienceClinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical ScienceSchool of Allied Medical Sciences, Shahroud University of Medical SciencesClinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical ScienceClinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical ScienceClinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical ScienceHealth Promotion Research Center, Zahedan University of Medical SciencesDepartment of Epidemiology, School of Public Health, Shahroud University of Medical SciencesHIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical SciencesOphthalmic Epidemiology Research Center, Shahroud University of Medical SciencesAbstract COVID-19 infection during pregnancy might be associated with maternal complications. This study aimed to investigate the impact of COVID-19 vaccination on the risk of miscarriage. This cohort study included 26,701 women of reproductive age (15–49) who were vaccinated with different vaccines (Sinopharm, Sputnik V, AZD1222 and CoVIran Barekat) between April 2021 and August 2022 in seven cities in Iran. Among them 459 women were pregnant and included in this analysis. All pregnant women were followed up until the end of their pregnancy. The mean age (standard deviation) of pregnant women was 31.7 (6.8) years. Among them, 50 miscarriage cases occurred. The cumulative incidence of miscarriage was 10.9%; 95% confidence intervals [CI] 8.0–13.8) in total, and 11.0% (5.9–16.1), 9.7% (4.4–14.9), 12.0% (5.9–18.2), and 11.1% (4.2–18.0) for AZD1222, Sputnik V, Sinopharm and Barekat vaccines respectively. Cumulative incidence rates by vaccine brands were not statistically significant (P value = 0.962). The mean (SD) time interval between conception and vaccination was 3.5 (3.8) weeks and it was 7.5 (2.7) weeks for the age of the fetus at miscarriage. In general, the miscarriage rate in women of reproductive age was 4.8 (95% CI 4.1–5.7) per 1000 women. The estimated incidence rates were not higher than expected; therefore, it can be argued that COVID − 19 vaccination with Sputnik V, Sinopharm, Barekat and AZD1222 does not increase the probability of miscarriage and the vaccines are therefore safe in this respect.https://doi.org/10.1038/s41598-025-06904-yVaccineCovid-19AbortionMiscarriageIran |
| spellingShingle | Fariba Shahraki-Sanavi Sajad Sahab-Negah Sairan Nili Parvin Mangolian shahrbabaki Alireza Ansari-moghaddam Mohammad Fereidouni Abtin Heidarzadeh Mostafa Enayatrad Sepideh Mahdavi Roqayeh Aliyari Mansooreh Fateh Hamidreza Khajeha Zahra Emamian Elahe Behmanesh Hossein Sheibani Maryam Abbaszadeh Reza Jafari Maryam Valikhani Ehsan Binesh Hamid Vahedi Sahar Shabestari Reza Chaman Hamid Sharifi Mohammad Hassan Emamian Evaluating miscarriage incidence after COVID-19 vaccination Scientific Reports Vaccine Covid-19 Abortion Miscarriage Iran |
| title | Evaluating miscarriage incidence after COVID-19 vaccination |
| title_full | Evaluating miscarriage incidence after COVID-19 vaccination |
| title_fullStr | Evaluating miscarriage incidence after COVID-19 vaccination |
| title_full_unstemmed | Evaluating miscarriage incidence after COVID-19 vaccination |
| title_short | Evaluating miscarriage incidence after COVID-19 vaccination |
| title_sort | evaluating miscarriage incidence after covid 19 vaccination |
| topic | Vaccine Covid-19 Abortion Miscarriage Iran |
| url | https://doi.org/10.1038/s41598-025-06904-y |
| work_keys_str_mv | AT faribashahrakisanavi evaluatingmiscarriageincidenceaftercovid19vaccination AT sajadsahabnegah evaluatingmiscarriageincidenceaftercovid19vaccination AT sairannili evaluatingmiscarriageincidenceaftercovid19vaccination AT parvinmangolianshahrbabaki evaluatingmiscarriageincidenceaftercovid19vaccination AT alirezaansarimoghaddam evaluatingmiscarriageincidenceaftercovid19vaccination AT mohammadfereidouni evaluatingmiscarriageincidenceaftercovid19vaccination AT abtinheidarzadeh evaluatingmiscarriageincidenceaftercovid19vaccination AT mostafaenayatrad evaluatingmiscarriageincidenceaftercovid19vaccination AT sepidehmahdavi evaluatingmiscarriageincidenceaftercovid19vaccination AT roqayehaliyari evaluatingmiscarriageincidenceaftercovid19vaccination AT mansoorehfateh evaluatingmiscarriageincidenceaftercovid19vaccination AT hamidrezakhajeha evaluatingmiscarriageincidenceaftercovid19vaccination AT zahraemamian evaluatingmiscarriageincidenceaftercovid19vaccination AT elahebehmanesh evaluatingmiscarriageincidenceaftercovid19vaccination AT hosseinsheibani evaluatingmiscarriageincidenceaftercovid19vaccination AT maryamabbaszadeh evaluatingmiscarriageincidenceaftercovid19vaccination AT rezajafari evaluatingmiscarriageincidenceaftercovid19vaccination AT maryamvalikhani evaluatingmiscarriageincidenceaftercovid19vaccination AT ehsanbinesh evaluatingmiscarriageincidenceaftercovid19vaccination AT hamidvahedi evaluatingmiscarriageincidenceaftercovid19vaccination AT saharshabestari evaluatingmiscarriageincidenceaftercovid19vaccination AT rezachaman evaluatingmiscarriageincidenceaftercovid19vaccination AT hamidsharifi evaluatingmiscarriageincidenceaftercovid19vaccination AT mohammadhassanemamian evaluatingmiscarriageincidenceaftercovid19vaccination |