The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

Abstract Triple‐negative breast cancer (TNBC) represents the most aggressive breast tumor subtype. However, the molecular determinants responsible for the metastatic TNBC phenotype are only partially understood. We here show that expression of the mitochondrial calcium uniporter (MCU), the selective...

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Main Authors: Anna Tosatto, Roberta Sommaggio, Carsten Kummerow, Robert B Bentham, Thomas S Blacker, Tunde Berecz, Michael R Duchen, Antonio Rosato, Ivan Bogeski, Gyorgy Szabadkai, Rosario Rizzuto, Cristina Mammucari
Format: Article
Language:English
Published: Springer Nature 2016-04-01
Series:EMBO Molecular Medicine
Subjects:
breast cancer
HIF‐1α
metastasis
mitochondrial Ca2+ uptake
reactive oxygen species
Online Access:https://doi.org/10.15252/emmm.201606255
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https://doi.org/10.15252/emmm.201606255

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