Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus
Lichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL-23 levels...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/5578568 |
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| author | Maryam Mardani Hossein Mofidi Ladan Dastgheib Sara Ranjbar Nasrin Hamidizadeh |
| author_facet | Maryam Mardani Hossein Mofidi Ladan Dastgheib Sara Ranjbar Nasrin Hamidizadeh |
| author_sort | Maryam Mardani |
| collection | DOAJ |
| description | Lichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL-23 levels in the patients with cutaneous and oral lichen planus compared to healthy controls. Method. The study included 30 cutaneous lichen planus patients, 20 oral lichen planus patients, and 33 control subjects. Five milliliters of peripheral blood was obtained from each patient, and the serum was separated. IL-23 levels were determined using the ELISA kit, and the data were analyzed using the Mann–Whitney test. Results. IL-23 levels in the patient serum with oral lichen planus (P value ≤ 0.001) were significantly higher than in controls. Furthermore, there were significant differences in IL-23 serum levels in the patients with cutaneous lichen planus compared to the healthy controls (P value ≤ 0.001). Moreover, IL-23 serum levels were statistically different between patients with cutaneous lichen planus and patients with oral lichen planus (P value ≤ 0.001). Based on the mean concentration of interleukin-23, IL-23 levels were higher in the patients with oral lichen planus than in the patients with cutaneous lichen planus. Conclusions. Elevated serum IL-23 levels in the patients with oral lichen planus may indicate that IL-23 plays a crucial role in the pathogenesis of oral lichen planus. However, more research is needed with a larger sample size. |
| format | Article |
| id | doaj-art-772da7fc5c084b098685cb4001e9d9d7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-772da7fc5c084b098685cb4001e9d9d72025-02-03T01:00:47ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/55785685578568Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen PlanusMaryam Mardani0Hossein Mofidi1Ladan Dastgheib2Sara Ranjbar3Nasrin Hamidizadeh4Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranOral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranLichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL-23 levels in the patients with cutaneous and oral lichen planus compared to healthy controls. Method. The study included 30 cutaneous lichen planus patients, 20 oral lichen planus patients, and 33 control subjects. Five milliliters of peripheral blood was obtained from each patient, and the serum was separated. IL-23 levels were determined using the ELISA kit, and the data were analyzed using the Mann–Whitney test. Results. IL-23 levels in the patient serum with oral lichen planus (P value ≤ 0.001) were significantly higher than in controls. Furthermore, there were significant differences in IL-23 serum levels in the patients with cutaneous lichen planus compared to the healthy controls (P value ≤ 0.001). Moreover, IL-23 serum levels were statistically different between patients with cutaneous lichen planus and patients with oral lichen planus (P value ≤ 0.001). Based on the mean concentration of interleukin-23, IL-23 levels were higher in the patients with oral lichen planus than in the patients with cutaneous lichen planus. Conclusions. Elevated serum IL-23 levels in the patients with oral lichen planus may indicate that IL-23 plays a crucial role in the pathogenesis of oral lichen planus. However, more research is needed with a larger sample size.http://dx.doi.org/10.1155/2021/5578568 |
| spellingShingle | Maryam Mardani Hossein Mofidi Ladan Dastgheib Sara Ranjbar Nasrin Hamidizadeh Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus Mediators of Inflammation |
| title | Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus |
| title_full | Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus |
| title_fullStr | Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus |
| title_full_unstemmed | Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus |
| title_short | Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus |
| title_sort | elevated serum interleukin 23 levels in patients with oral and cutaneous lichen planus |
| url | http://dx.doi.org/10.1155/2021/5578568 |
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