Malignant Catatonia Mimicking Pheochromocytoma
Malignant catatonia is an unusual and highly fatal neuropsychiatric condition which can present with clinical and biochemical manifestations similar to those of pheochromocytoma. Differentiating between the two diseases is essential as management options greatly diverge. We describe a case of malign...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/815821 |
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| author | Sophia Wong Barbara Hughes Morris Pudek Dailin Li |
| author_facet | Sophia Wong Barbara Hughes Morris Pudek Dailin Li |
| author_sort | Sophia Wong |
| collection | DOAJ |
| description | Malignant catatonia is an unusual and highly fatal neuropsychiatric condition which can present with clinical and biochemical manifestations similar to those of pheochromocytoma. Differentiating between the two diseases is essential as management options greatly diverge. We describe a case of malignant catatonia in a 20-year-old male who presented with concurrent psychotic symptoms and autonomic instability, with markedly increased 24-hour urinary levels of norepinephrine at 1752 nmol/day (normal, 89–470 nmol/day), epinephrine at 1045 nmol/day (normal, <160 nmol/day), and dopamine at 7.9 μmol/day (normal, 0.4–3.3 μmol/day). The patient was treated with multiple sessions of electroconvulsive therapy, which led to complete clinical resolution. Repeat urine collections within weeks of this presenting event revealed normalization or near normalization of his catecholamine and metanephrine levels. Malignant catatonia should be considered in the differential diagnosis of the hypercatecholamine state, particularly in a patient who also exhibits concurrent catatonic features. |
| format | Article |
| id | doaj-art-772c65a913624176b9e4cc6d509be71c |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-772c65a913624176b9e4cc6d509be71c2025-02-03T01:02:13ZengWileyCase Reports in Endocrinology2090-65012090-651X2013-01-01201310.1155/2013/815821815821Malignant Catatonia Mimicking PheochromocytomaSophia Wong0Barbara Hughes1Morris Pudek2Dailin Li3Department of Pathology and Laboratory Medicine, University of British Columbia, 855 West 12th Avenue, Vancouver, BC, V5Z 1M9, CanadaDepartment of Medicine, Ridge Meadows Hospital, 11666 Laity Street, Maple Ridge, BC, V2X 7G5, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, 855 West 12th Avenue, Vancouver, BC, V5Z 1M9, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, 855 West 12th Avenue, Vancouver, BC, V5Z 1M9, CanadaMalignant catatonia is an unusual and highly fatal neuropsychiatric condition which can present with clinical and biochemical manifestations similar to those of pheochromocytoma. Differentiating between the two diseases is essential as management options greatly diverge. We describe a case of malignant catatonia in a 20-year-old male who presented with concurrent psychotic symptoms and autonomic instability, with markedly increased 24-hour urinary levels of norepinephrine at 1752 nmol/day (normal, 89–470 nmol/day), epinephrine at 1045 nmol/day (normal, <160 nmol/day), and dopamine at 7.9 μmol/day (normal, 0.4–3.3 μmol/day). The patient was treated with multiple sessions of electroconvulsive therapy, which led to complete clinical resolution. Repeat urine collections within weeks of this presenting event revealed normalization or near normalization of his catecholamine and metanephrine levels. Malignant catatonia should be considered in the differential diagnosis of the hypercatecholamine state, particularly in a patient who also exhibits concurrent catatonic features.http://dx.doi.org/10.1155/2013/815821 |
| spellingShingle | Sophia Wong Barbara Hughes Morris Pudek Dailin Li Malignant Catatonia Mimicking Pheochromocytoma Case Reports in Endocrinology |
| title | Malignant Catatonia Mimicking Pheochromocytoma |
| title_full | Malignant Catatonia Mimicking Pheochromocytoma |
| title_fullStr | Malignant Catatonia Mimicking Pheochromocytoma |
| title_full_unstemmed | Malignant Catatonia Mimicking Pheochromocytoma |
| title_short | Malignant Catatonia Mimicking Pheochromocytoma |
| title_sort | malignant catatonia mimicking pheochromocytoma |
| url | http://dx.doi.org/10.1155/2013/815821 |
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