Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process
The objective of the study is to assess the effect of rs6707530 polymorphism of the FN1 gene and rs1150754 polymorphism of the TNXB gene on the healing of lung tissue destruction in patients with newly detected pulmonary tuberculosis.Subjects and methods. 82 patients older 18 years with newly diagno...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-09-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1447 |
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| author | K. Yu. Samsonov A. V. Mordyk A. R. Аroyan T. L. Batischeva O. G. Ivanova |
| author_facet | K. Yu. Samsonov A. V. Mordyk A. R. Аroyan T. L. Batischeva O. G. Ivanova |
| author_sort | K. Yu. Samsonov |
| collection | DOAJ |
| description | The objective of the study is to assess the effect of rs6707530 polymorphism of the FN1 gene and rs1150754 polymorphism of the TNXB gene on the healing of lung tissue destruction in patients with newly detected pulmonary tuberculosis.Subjects and methods. 82 patients older 18 years with newly diagnosed pulmonary tuberculosis with destruction were enrolled in the study. X-ray data were assessed on the 2nd, 4th and 6th months of the study. Patients were divided into 2 groups depending on the efficacy of chemotherapy intensive phase.Results. In the group of patients with an effective course of chemotherapy, the frequency of carriers of G allele (p < 0.001) and T/G genotype (p = 0.01) in rs6707530 locus of the FN1 gene was higher. While T/T genotype (p = 0.002) and T allele (p < 0.001) prevailed among the patients with persisting destruction of lung tissue after the intensive phase of chemotherapy. |
| format | Article |
| id | doaj-art-7723dbd1b5cc4b4d870492b34222425f |
| institution | DOAJ |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2020-09-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-7723dbd1b5cc4b4d870492b34222425f2025-08-20T03:02:41ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062020-09-0198871310.21292/2075-1230-2020-98-8-7-131446Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined processK. Yu. Samsonov0A. V. Mordyk1A. R. Аroyan2T. L. Batischeva3O. G. Ivanova4Omsk State Medical UniversityOmsk State Medical UniversityClinical TB DispensaryClinical TB DispensaryOmsk State Medical UniversityThe objective of the study is to assess the effect of rs6707530 polymorphism of the FN1 gene and rs1150754 polymorphism of the TNXB gene on the healing of lung tissue destruction in patients with newly detected pulmonary tuberculosis.Subjects and methods. 82 patients older 18 years with newly diagnosed pulmonary tuberculosis with destruction were enrolled in the study. X-ray data were assessed on the 2nd, 4th and 6th months of the study. Patients were divided into 2 groups depending on the efficacy of chemotherapy intensive phase.Results. In the group of patients with an effective course of chemotherapy, the frequency of carriers of G allele (p < 0.001) and T/G genotype (p = 0.01) in rs6707530 locus of the FN1 gene was higher. While T/T genotype (p = 0.002) and T allele (p < 0.001) prevailed among the patients with persisting destruction of lung tissue after the intensive phase of chemotherapy.https://www.tibl-journal.com/jour/article/view/1447pulmonary tuberculosisgene polymorphismfibronectintenascinlung tissue destruction |
| spellingShingle | K. Yu. Samsonov A. V. Mordyk A. R. Аroyan T. L. Batischeva O. G. Ivanova Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process Туберкулез и болезни лёгких pulmonary tuberculosis gene polymorphism fibronectin tenascin lung tissue destruction |
| title | Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process |
| title_full | Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process |
| title_fullStr | Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process |
| title_full_unstemmed | Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process |
| title_short | Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process |
| title_sort | reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process |
| topic | pulmonary tuberculosis gene polymorphism fibronectin tenascin lung tissue destruction |
| url | https://www.tibl-journal.com/jour/article/view/1447 |
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