Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer Treatment
Breast cancer treatment, including surgery, chemotherapy, radiotherapy, and endocrine therapy, can affect the microbiome and microenvironment of the human body. The present study examined how the microbiome changes before and after treatment in patients with breast cancer and explored variations in...
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MDPI AG
2025-05-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/5/1057 |
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| author | Jeongshin An Hyungju Kwon Young Ju Kim Byung-In Moon |
| author_facet | Jeongshin An Hyungju Kwon Young Ju Kim Byung-In Moon |
| author_sort | Jeongshin An |
| collection | DOAJ |
| description | Breast cancer treatment, including surgery, chemotherapy, radiotherapy, and endocrine therapy, can affect the microbiome and microenvironment of the human body. The present study examined how the microbiome changes before and after treatment in patients with breast cancer and explored variations in the expression of putative proteins linked to these shifts. Forty-five patients enrolled in this study, and blood samples were collected and sequenced to analyze microbiome composition. Using these sequences, we estimated and compared the putative protein expression levels. In addition, complete blood count results were analyzed to evaluate treatment-induced alterations. The findings indicate that treatment leads to microbiome modifications associated with changes in the human microenvironment. Moreover, key putative proteins involved in these processes were identified. This study provides valuable insights into how breast cancer treatment affects the microbiome and helps elucidate the potential role of microbial protein expression in patient outcomes. |
| format | Article |
| id | doaj-art-771eae8f4fbc4878b21ce50e204238cd |
| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-771eae8f4fbc4878b21ce50e204238cd2025-08-20T02:33:51ZengMDPI AGMicroorganisms2076-26072025-05-01135105710.3390/microorganisms13051057Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer TreatmentJeongshin An0Hyungju Kwon1Young Ju Kim2Byung-In Moon3Institute of Convergence Medicine Research, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Republic of KoreaDepartment of Surgery, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Republic of KoreaDepartment of Obstetrics and Gynecology, Ewha Medical Institute and College of Medicine, Ewha Womans University, Seoul 07804, Republic of KoreaDepartment of Surgery, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Republic of KoreaBreast cancer treatment, including surgery, chemotherapy, radiotherapy, and endocrine therapy, can affect the microbiome and microenvironment of the human body. The present study examined how the microbiome changes before and after treatment in patients with breast cancer and explored variations in the expression of putative proteins linked to these shifts. Forty-five patients enrolled in this study, and blood samples were collected and sequenced to analyze microbiome composition. Using these sequences, we estimated and compared the putative protein expression levels. In addition, complete blood count results were analyzed to evaluate treatment-induced alterations. The findings indicate that treatment leads to microbiome modifications associated with changes in the human microenvironment. Moreover, key putative proteins involved in these processes were identified. This study provides valuable insights into how breast cancer treatment affects the microbiome and helps elucidate the potential role of microbial protein expression in patient outcomes.https://www.mdpi.com/2076-2607/13/5/1057breast cancermicrobiomecancer treatmentneutropeniaanemia |
| spellingShingle | Jeongshin An Hyungju Kwon Young Ju Kim Byung-In Moon Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer Treatment Microorganisms breast cancer microbiome cancer treatment neutropenia anemia |
| title | Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer Treatment |
| title_full | Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer Treatment |
| title_fullStr | Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer Treatment |
| title_full_unstemmed | Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer Treatment |
| title_short | Microbiome-Induced Microenvironmental Changes Before and After Breast Cancer Treatment |
| title_sort | microbiome induced microenvironmental changes before and after breast cancer treatment |
| topic | breast cancer microbiome cancer treatment neutropenia anemia |
| url | https://www.mdpi.com/2076-2607/13/5/1057 |
| work_keys_str_mv | AT jeongshinan microbiomeinducedmicroenvironmentalchangesbeforeandafterbreastcancertreatment AT hyungjukwon microbiomeinducedmicroenvironmentalchangesbeforeandafterbreastcancertreatment AT youngjukim microbiomeinducedmicroenvironmentalchangesbeforeandafterbreastcancertreatment AT byunginmoon microbiomeinducedmicroenvironmentalchangesbeforeandafterbreastcancertreatment |