A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cells
Despite a substantial progress in the development of strategies against cancer, cancer still remains a major global health issue due to a high recurrence rate, and severe side effects, leading basic medical scientists and clinical specialists toward more efficient diagnostics, prognostics, and thera...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | The Journal of Liquid Biopsy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950195424000341 |
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| author | Nazila Bahmaie Ozen Ozensoy Guler Ender Simsek |
| author_facet | Nazila Bahmaie Ozen Ozensoy Guler Ender Simsek |
| author_sort | Nazila Bahmaie |
| collection | DOAJ |
| description | Despite a substantial progress in the development of strategies against cancer, cancer still remains a major global health issue due to a high recurrence rate, and severe side effects, leading basic medical scientists and clinical specialists toward more efficient diagnostics, prognostics, and therapeutics. Therefore, there is an imperative need for a comprehensive understanding on the cellular immunopathophysiology involved in the tumor microenvironment. In addition, results from a wide range of studies depicted that an aberration in the cellular mechanisms and immunopathophysiological interactions like Circulating Tumor Cells (CTCs) plays an indispensable role in the metastasis and tumor progression, revolutionizing cancer management by offering non-invasive detection methods and a real-time monitoring of tumor dynamics. Moreover, CTCs can clarify the tumor heterogeneity and the evolution of resistance mechanisms, aiding in the early detection of tumors and informing personalized treatment strategies. An increase in CTCs count can be associated with a worsened cancer prognosis, providing promising biomarkers for tumor phenotyping, tumor spreading or relapse, and monitoring the treatment response in patients with cancer. Hence, this systematic review aims to highlight the diagnostic, prognostic, and therapeutic potentials of CTCs, necessitating further investigations and an interdisciplinary collaboration among basic medical scientists and oncologists to address the current gaps in the strategies of cancer management, precisely improving patient-care and optimized clinical outcomes. |
| format | Article |
| id | doaj-art-7718f9f6b4d540a5aefb23799a55753e |
| institution | OA Journals |
| issn | 2950-1954 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Liquid Biopsy |
| spelling | doaj-art-7718f9f6b4d540a5aefb23799a55753e2025-08-20T02:34:38ZengElsevierThe Journal of Liquid Biopsy2950-19542024-12-01610016910.1016/j.jlb.2024.100169A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cellsNazila Bahmaie0Ozen Ozensoy Guler1Ender Simsek2Department of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), TurkeyDepartment of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), TurkeyCorresponding author.; Department of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), TurkeyDespite a substantial progress in the development of strategies against cancer, cancer still remains a major global health issue due to a high recurrence rate, and severe side effects, leading basic medical scientists and clinical specialists toward more efficient diagnostics, prognostics, and therapeutics. Therefore, there is an imperative need for a comprehensive understanding on the cellular immunopathophysiology involved in the tumor microenvironment. In addition, results from a wide range of studies depicted that an aberration in the cellular mechanisms and immunopathophysiological interactions like Circulating Tumor Cells (CTCs) plays an indispensable role in the metastasis and tumor progression, revolutionizing cancer management by offering non-invasive detection methods and a real-time monitoring of tumor dynamics. Moreover, CTCs can clarify the tumor heterogeneity and the evolution of resistance mechanisms, aiding in the early detection of tumors and informing personalized treatment strategies. An increase in CTCs count can be associated with a worsened cancer prognosis, providing promising biomarkers for tumor phenotyping, tumor spreading or relapse, and monitoring the treatment response in patients with cancer. Hence, this systematic review aims to highlight the diagnostic, prognostic, and therapeutic potentials of CTCs, necessitating further investigations and an interdisciplinary collaboration among basic medical scientists and oncologists to address the current gaps in the strategies of cancer management, precisely improving patient-care and optimized clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2950195424000341CancerCirculating tumor cellsCellular immunologyClinical applicationsPrecision medicineTumor microenvironment |
| spellingShingle | Nazila Bahmaie Ozen Ozensoy Guler Ender Simsek A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cells The Journal of Liquid Biopsy Cancer Circulating tumor cells Cellular immunology Clinical applications Precision medicine Tumor microenvironment |
| title | A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cells |
| title_full | A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cells |
| title_fullStr | A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cells |
| title_full_unstemmed | A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cells |
| title_short | A revolutionary era in advancing precision immuno-oncology; role of circulating tumor cells |
| title_sort | revolutionary era in advancing precision immuno oncology role of circulating tumor cells |
| topic | Cancer Circulating tumor cells Cellular immunology Clinical applications Precision medicine Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2950195424000341 |
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