3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings
Abstract Designing three‐dimensional (3D)‐printable hydrogels presents a significant challenge, particularly in maintaining the polymer concentration at minimal levels while ensuring that the printing process can be cell‐friendly at room temperature. This study aims to examine the feasibility of des...
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Wiley-VCH
2025-06-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202400913 |
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| author | Ehsan Zeimaran Sara Pourshahrestani Jonas Röder Rainer Detsch Aldo R. Boccaccini |
| author_facet | Ehsan Zeimaran Sara Pourshahrestani Jonas Röder Rainer Detsch Aldo R. Boccaccini |
| author_sort | Ehsan Zeimaran |
| collection | DOAJ |
| description | Abstract Designing three‐dimensional (3D)‐printable hydrogels presents a significant challenge, particularly in maintaining the polymer concentration at minimal levels while ensuring that the printing process can be cell‐friendly at room temperature. This study aims to examine the feasibility of designing multi‐crosslinked hydrogels composed of methacrylate‐functionalized alginate dialdehyde (ADAMA) and different concentrations of gelatin methacrylate (GelMA). Cobalt‐doped mesoporous bioactive glass nanoparticles (Co‐MBGNs) are incorporated into the hydrogels to further tailor their mechanical and biological properties. The hydrogels, crosslinked under UV and immersed in calcium chloride solution, show high elasticity and fatigue resistance over five compression cycles. The inclusion of Co‐MBGNs enhances the mechanical properties while cell viability is higher in the pure polymeric hydrogels. The nanocomposites promote cell aggregate formation. The non‐cytotoxic hydrogel supernatants induce NHDF cell migration at rates similar to or even faster than the control group. The printability of hydrogels is also examined through extrusion‐bioprinting approach. The room‐temperature printing is only possible for the hydrogels made of 5 wt% of GelMA and 2.5 wt% of ADAMA. The 3D‐printed constructs show impressive elasticity and are easy to handle. These findings can offer valuable insights into the development of mechanically robust and customizable wound dressings. |
| format | Article |
| id | doaj-art-7713fba767ed4a2da1f75c504e9eee99 |
| institution | Kabale University |
| issn | 2196-7350 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-7713fba767ed4a2da1f75c504e9eee992025-08-20T03:45:49ZengWiley-VCHAdvanced Materials Interfaces2196-73502025-06-011211n/an/a10.1002/admi.2024009133D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound DressingsEhsan Zeimaran0Sara Pourshahrestani1Jonas Röder2Rainer Detsch3Aldo R. Boccaccini4Institute of Biomaterials Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Cauerstrasse 6 91058 Erlangen GermanyInstitute of Biomaterials Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Cauerstrasse 6 91058 Erlangen GermanyInstitute of Biomaterials Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Cauerstrasse 6 91058 Erlangen GermanyInstitute of Biomaterials Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Cauerstrasse 6 91058 Erlangen GermanyInstitute of Biomaterials Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Cauerstrasse 6 91058 Erlangen GermanyAbstract Designing three‐dimensional (3D)‐printable hydrogels presents a significant challenge, particularly in maintaining the polymer concentration at minimal levels while ensuring that the printing process can be cell‐friendly at room temperature. This study aims to examine the feasibility of designing multi‐crosslinked hydrogels composed of methacrylate‐functionalized alginate dialdehyde (ADAMA) and different concentrations of gelatin methacrylate (GelMA). Cobalt‐doped mesoporous bioactive glass nanoparticles (Co‐MBGNs) are incorporated into the hydrogels to further tailor their mechanical and biological properties. The hydrogels, crosslinked under UV and immersed in calcium chloride solution, show high elasticity and fatigue resistance over five compression cycles. The inclusion of Co‐MBGNs enhances the mechanical properties while cell viability is higher in the pure polymeric hydrogels. The nanocomposites promote cell aggregate formation. The non‐cytotoxic hydrogel supernatants induce NHDF cell migration at rates similar to or even faster than the control group. The printability of hydrogels is also examined through extrusion‐bioprinting approach. The room‐temperature printing is only possible for the hydrogels made of 5 wt% of GelMA and 2.5 wt% of ADAMA. The 3D‐printed constructs show impressive elasticity and are easy to handle. These findings can offer valuable insights into the development of mechanically robust and customizable wound dressings.https://doi.org/10.1002/admi.202400913GelMAmesoporous bioactive glass nanoparticlesmethacrylated alginate dialdehydeprintable hydrogelswound healing |
| spellingShingle | Ehsan Zeimaran Sara Pourshahrestani Jonas Röder Rainer Detsch Aldo R. Boccaccini 3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings Advanced Materials Interfaces GelMA mesoporous bioactive glass nanoparticles methacrylated alginate dialdehyde printable hydrogels wound healing |
| title | 3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings |
| title_full | 3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings |
| title_fullStr | 3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings |
| title_full_unstemmed | 3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings |
| title_short | 3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings |
| title_sort | 3d printing of photocrosslinked alginate dialdehyde gelatin hydrogels reinforced with cobalt containing mesoporous bioactive glass nanoparticles for developing skin wound dressings |
| topic | GelMA mesoporous bioactive glass nanoparticles methacrylated alginate dialdehyde printable hydrogels wound healing |
| url | https://doi.org/10.1002/admi.202400913 |
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