Therapy of acute hepatitis C infection
Background. Hepatitis C viral infection is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The progression of acute to chronic infection occurs in 50-90% of cases. There is no standard therapy for acute HCV infection. Comparative studies are required to verify the o...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2005-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500503247D.pdf |
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| _version_ | 1849409064864317440 |
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| author | Đokić Milomir Begović Vesna |
| author_facet | Đokić Milomir Begović Vesna |
| author_sort | Đokić Milomir |
| collection | DOAJ |
| description | Background. Hepatitis C viral infection is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The progression of acute to chronic infection occurs in 50-90% of cases. There is no standard therapy for acute HCV infection. Comparative studies are required to verify the optimal doses, dosage schedules and the treatment duration, and to establish the optimal treatment for acute hepatitis C. Recent reports have demonstrated that early application of interferon alpha was a treatment of choice for acute HCV infection. The addition of ribavirinin in the treatment of acute HCV infection, and HCV genotype, did not improve the end-of treatment responses. It is important to consider the treatment of acute HCV infection before it progresses to chronic state. Case Report. Beneficial effect of interferon therapy in a patient with acute hepatitis C is presented. Early treatment with 3 MIU interferon alpha, three times a week, within six-months, resulted in the normal serum aminotransferases, and good virological response in our patient. Conclusion. Interferon therapy significantly increased the probability of obtaining normal serum aminotransferases and undetectable HCV RNA, following acute HCV infection. |
| format | Article |
| id | doaj-art-770d1ada57fa41c195df0f9683ec0acd |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-770d1ada57fa41c195df0f9683ec0acd2025-08-20T03:35:37ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502005-01-0162324724910.2298/VSP0503247DTherapy of acute hepatitis C infectionĐokić MilomirBegović VesnaBackground. Hepatitis C viral infection is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The progression of acute to chronic infection occurs in 50-90% of cases. There is no standard therapy for acute HCV infection. Comparative studies are required to verify the optimal doses, dosage schedules and the treatment duration, and to establish the optimal treatment for acute hepatitis C. Recent reports have demonstrated that early application of interferon alpha was a treatment of choice for acute HCV infection. The addition of ribavirinin in the treatment of acute HCV infection, and HCV genotype, did not improve the end-of treatment responses. It is important to consider the treatment of acute HCV infection before it progresses to chronic state. Case Report. Beneficial effect of interferon therapy in a patient with acute hepatitis C is presented. Early treatment with 3 MIU interferon alpha, three times a week, within six-months, resulted in the normal serum aminotransferases, and good virological response in our patient. Conclusion. Interferon therapy significantly increased the probability of obtaining normal serum aminotransferases and undetectable HCV RNA, following acute HCV infection.http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500503247D.pdfhepatitis Chepacivirusinterferon-alpharibavirintransaminases |
| spellingShingle | Đokić Milomir Begović Vesna Therapy of acute hepatitis C infection Vojnosanitetski Pregled hepatitis C hepacivirus interferon-alpha ribavirin transaminases |
| title | Therapy of acute hepatitis C infection |
| title_full | Therapy of acute hepatitis C infection |
| title_fullStr | Therapy of acute hepatitis C infection |
| title_full_unstemmed | Therapy of acute hepatitis C infection |
| title_short | Therapy of acute hepatitis C infection |
| title_sort | therapy of acute hepatitis c infection |
| topic | hepatitis C hepacivirus interferon-alpha ribavirin transaminases |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500503247D.pdf |
| work_keys_str_mv | AT đokicmilomir therapyofacutehepatitiscinfection AT begovicvesna therapyofacutehepatitiscinfection |