SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling

SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling

Abstract ORF3a, the most abundantly expressed accessory protein of SARS-CoV-2, plays an essential role in virus egress by inactivating lysosomes through their deacidification. However, the mechanism underlying this process remains unclear. While seminal studies suggested ORF3a being a cation-selecti...

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Bibliographic Details
Main Authors: Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07442-5
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