SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T‐Cell Lymphoma

SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T‐Cell Lymphoma

Abstract Peripheral T‐cell lymphoma (PTCL) is a heterogeneous group of mature T‐cell malignancies with poor prognosis. Therefore, improved therapies are urgently required to improve patient outcomes. In this study, metabolic inhibitor drug screening reveals that quinacrine elicits excellent antitumo...

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Bibliographic Details
Main Authors: Yimin Ren, Lei Fan, Ling Wang, Yanping Liu, Jie Zhang, Boya Wang, Ruize Chen, Xiao Chen, Lingyu Zhuang, Yaping Zhang, Handong Sun, Jianyong Li, Wenyu Shi, Hui Jin
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
arginine
drug repurposing
immune escape
peripheral T‐cell lymphoma
solute carrier
transcription regulation
Online Access:https://doi.org/10.1002/advs.202415698
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