Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy

Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy

Background & Aims: The dynamics of HBV viral load (VL) in patients with chronic hepatitis B (CHB) on nucleos(t)ide analogue (NA) treatment and its relationship with liver disease are poorly understood. We aimed to study longitudinal VL patterns and their associations with CHB clinical outcom...

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Main Authors: Tingyan Wang, Cori Campbell, Alexander J. Stockdale, Stacy Todd, Karl McIntyre, Andrew Frankland, Jakub Jaworski, Ben Glampson, Dimitri Papadimitriou, Luca Mercuri, Erik Mayer, Christopher R. Jones, Hizni Salih, Gail Roadknight, Stephanie Little, Theresa Noble, Kinga A. Várnai, Cai Davis, Ashley I. Heinson, Michael George, Florina Borca, Louise English, Luis Romão, David Ramlakhan, Kerrie Woods, Jim Davies, Eleni Nastouli, Salim I. Khakoo, William Gelson, Graham S. Cooke, Eleanor Barnes, Philippa C. Matthews, Stephen Ryder, Ahmed Elsharkawy, Nicholas Easom, William Bernal, Shazaad Ahmad, Douglas Macdonald, Simon Stanworth, Suzanne Maynard, Ashley Heinson, Heidi MacNaughton, Yun Kim, Josune Olza Meneses, Timothy Roberts, Heather Rogers, Lara Roberts, Finola Higgins, Javier Vilar, Ruth Norris, George Tilston, Ilina Serafimova, Sarah Montague, Juliette Verheyden, Irene Juurlink, Kathryn Jack, Alex Waldren-Glenn, Lizzie Poole, Victoria Day, Berit Reglar
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:JHEP Reports
Subjects:
HBV
Viral load
Longitudinal
Liver fibrosis
Cirrhosis
Antiviral treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924002337
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