Immunogenicity, safety and tolerability of 15-valent pneumococcal conjugate vaccine (V114) compared to 13-valent pneumococcal conjugate vaccine (PCV-13) in healthy infants: A systematic review and meta-analysis

Immunogenicity, safety and tolerability of 15-valent pneumococcal conjugate vaccine (V114) compared to 13-valent pneumococcal conjugate vaccine (PCV-13) in healthy infants: A systematic review and meta-analysis

Introduction: Streptococcus pneumoniae is a major cause of infectious diseases, particularly in children under 5, leading to approximately 300,000 deaths annually. The introduction of pneumococcal conjugate vaccines (PCVs), such as PCV13, has significantly reduced invasive pneumococcal disease (IPD)...

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Main Authors: Muhammad Zain Ul Haq, Hamza Irfan, Muhammad Shahmeer Ullah Shah, Anusha Sumbal, Sanila Mughal, Saad Ashraf, Areeba Aamir Ali Basaria, Abdullah, Muhammad Aaqib Chacho, Biruk Demisse Ayalew
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Vaccine: X
Subjects:
Pneumococcal conjugate vaccines
PCV13
V114
Immunogenicity
Safety
Meta-analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136225000488
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