High alert medications off the radar: A systematic review
Objective: To identify new drugs that present an increased risk of causing significant damage to critically ill patients due to failure in the administration process. Method: The systematic literature review was conducted in the PubMed, Lilacs, Scopus, Web of Science and gray literature. The year in...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Exploratory Research in Clinical and Social Pharmacy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667276624001483 |
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| author | Michelle Santos Menezes Fernanda Valença-Feitosa Aline Santana Góes Millena Rakel dos Santos Laila Santana Silva Sylmara Nayara Pereira dos Santos Divaldo Pereira de Lyra Jr Alfredo Dias de Oliveira Filho |
| author_facet | Michelle Santos Menezes Fernanda Valença-Feitosa Aline Santana Góes Millena Rakel dos Santos Laila Santana Silva Sylmara Nayara Pereira dos Santos Divaldo Pereira de Lyra Jr Alfredo Dias de Oliveira Filho |
| author_sort | Michelle Santos Menezes |
| collection | DOAJ |
| description | Objective: To identify new drugs that present an increased risk of causing significant damage to critically ill patients due to failure in the administration process. Method: The systematic literature review was conducted in the PubMed, Lilacs, Scopus, Web of Science and gray literature. The year in which the study was conducted was not restricted. Results: The initial search in the databases identified 1477 studies. Fifty manuscripts were selected for evaluation of the full text, at the end of which seven articles were included in this systematic review. As for the characteristic of medication errors, the highest frequency occurred in the administration and prescription phases. In all included studies, incidents with drugs that led to damage were observed. The drugs that are not included in the official lists as High Alert Medications (HAM) that presented an increased risk of causing damage due to medication errors found were: risperidone and piperacycline + tazobactan, in addition to the Infectious Agent class. Conclusion: The results revealed that in fact there are drugs not listed as HAM that, when used in errors, promote greater risks of generating damage in critically ill patients. These described drugs should be considered for inclusion in future official lists of HAM. |
| format | Article |
| id | doaj-art-77007976beff4963a8163b8fc650b7b3 |
| institution | OA Journals |
| issn | 2667-2766 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Exploratory Research in Clinical and Social Pharmacy |
| spelling | doaj-art-77007976beff4963a8163b8fc650b7b32025-08-20T02:00:45ZengElsevierExploratory Research in Clinical and Social Pharmacy2667-27662025-03-011710055110.1016/j.rcsop.2024.100551High alert medications off the radar: A systematic reviewMichelle Santos Menezes0Fernanda Valença-Feitosa1Aline Santana Góes2Millena Rakel dos Santos3Laila Santana Silva4Sylmara Nayara Pereira dos Santos5Divaldo Pereira de Lyra Jr6Alfredo Dias de Oliveira Filho7Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilLaboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilLaboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilLaboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilLaboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilLaboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilLaboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilCorresponding author at: Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Avenida Marcelo Déda Chagas, Cidade Universitária “Prof. José Aloísio Campos”, Jardim Rosa Elze, São Cristóvão, Sergipe CEP: 49100-000, Brazil.; Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, BrazilObjective: To identify new drugs that present an increased risk of causing significant damage to critically ill patients due to failure in the administration process. Method: The systematic literature review was conducted in the PubMed, Lilacs, Scopus, Web of Science and gray literature. The year in which the study was conducted was not restricted. Results: The initial search in the databases identified 1477 studies. Fifty manuscripts were selected for evaluation of the full text, at the end of which seven articles were included in this systematic review. As for the characteristic of medication errors, the highest frequency occurred in the administration and prescription phases. In all included studies, incidents with drugs that led to damage were observed. The drugs that are not included in the official lists as High Alert Medications (HAM) that presented an increased risk of causing damage due to medication errors found were: risperidone and piperacycline + tazobactan, in addition to the Infectious Agent class. Conclusion: The results revealed that in fact there are drugs not listed as HAM that, when used in errors, promote greater risks of generating damage in critically ill patients. These described drugs should be considered for inclusion in future official lists of HAM.http://www.sciencedirect.com/science/article/pii/S2667276624001483Critical patientMedication errorsDamage |
| spellingShingle | Michelle Santos Menezes Fernanda Valença-Feitosa Aline Santana Góes Millena Rakel dos Santos Laila Santana Silva Sylmara Nayara Pereira dos Santos Divaldo Pereira de Lyra Jr Alfredo Dias de Oliveira Filho High alert medications off the radar: A systematic review Exploratory Research in Clinical and Social Pharmacy Critical patient Medication errors Damage |
| title | High alert medications off the radar: A systematic review |
| title_full | High alert medications off the radar: A systematic review |
| title_fullStr | High alert medications off the radar: A systematic review |
| title_full_unstemmed | High alert medications off the radar: A systematic review |
| title_short | High alert medications off the radar: A systematic review |
| title_sort | high alert medications off the radar a systematic review |
| topic | Critical patient Medication errors Damage |
| url | http://www.sciencedirect.com/science/article/pii/S2667276624001483 |
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