Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis
Vaccines are commonly used in the prevention of infectious diseases. The basic principle of vaccination is to use specific antigens, endogenous or exogenous to stimulate immunity against the specific antigens or cells producing them. Autoantigen or oligo vaccination has been used for disease animal...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1638462 |
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| _version_ | 1849409061687132160 |
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| author | Kongye Lu Benli Su Xiuxiang Meng |
| author_facet | Kongye Lu Benli Su Xiuxiang Meng |
| author_sort | Kongye Lu |
| collection | DOAJ |
| description | Vaccines are commonly used in the prevention of infectious diseases. The basic principle of vaccination is to use specific antigens, endogenous or exogenous to stimulate immunity against the specific antigens or cells producing them. Autoantigen or oligo vaccination has been used for disease animal models. More recently humanized monoclonal antibodies have been successfully used for the treatment of neoplastic disorders or familial hypercholesterolemia. Humanized monoclonal antibody therapy needs repeated injection, and the therapy is expensive. Therapeutic vaccination can lead to persistent immunized or immune tolerant against the therapeutic molecule(s) or site. However, immunization against those endogenous substances may also elicit persistent autoimmune reaction or destruction that do harm to health. Therefore, rigorous studies are needed before any clinical application. In this review, we briefly reviewed vaccines used in protection against common metabolic diseases including atherosclerosis, hypertension, and diabetes mellitus. |
| format | Article |
| id | doaj-art-76fdeff337b24b9787b243e943175462 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-76fdeff337b24b9787b243e9431754622025-08-20T03:35:37ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/16384621638462Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and AtherosclerosisKongye Lu0Benli Su1Xiuxiang Meng2College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning 116044, ChinaDepartment of Clinical Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, ChinaCollege of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning 116044, ChinaVaccines are commonly used in the prevention of infectious diseases. The basic principle of vaccination is to use specific antigens, endogenous or exogenous to stimulate immunity against the specific antigens or cells producing them. Autoantigen or oligo vaccination has been used for disease animal models. More recently humanized monoclonal antibodies have been successfully used for the treatment of neoplastic disorders or familial hypercholesterolemia. Humanized monoclonal antibody therapy needs repeated injection, and the therapy is expensive. Therapeutic vaccination can lead to persistent immunized or immune tolerant against the therapeutic molecule(s) or site. However, immunization against those endogenous substances may also elicit persistent autoimmune reaction or destruction that do harm to health. Therefore, rigorous studies are needed before any clinical application. In this review, we briefly reviewed vaccines used in protection against common metabolic diseases including atherosclerosis, hypertension, and diabetes mellitus.http://dx.doi.org/10.1155/2018/1638462 |
| spellingShingle | Kongye Lu Benli Su Xiuxiang Meng Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis Journal of Diabetes Research |
| title | Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis |
| title_full | Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis |
| title_fullStr | Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis |
| title_full_unstemmed | Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis |
| title_short | Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis |
| title_sort | recent advances in the development of vaccines for diabetes hypertension and atherosclerosis |
| url | http://dx.doi.org/10.1155/2018/1638462 |
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