Comprehensive Analysis of the Effects of Sacubitril/Valsartan According to Sex Among Patients With Heart Failure and Reduced Ejection Fraction in PARADIGM‐HF

Comprehensive Analysis of the Effects of Sacubitril/Valsartan According to Sex Among Patients With Heart Failure and Reduced Ejection Fraction in PARADIGM‐HF

Background Women with heart failure (HF) ejection fraction appeared to respond more favorably to sacubitril/valsartan, compared with valsartan, than men in PARAGON‐HF (Prospective Comparison of ARNI With ARB Global Outcomes in Heart Failure With Preserved Ejection Fraction), driven by a greater redu...

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Main Authors: Misato Chimura, Jawad H. Butt, Shingo Matsumoto, Eoghan G. M. McMurray, Alasdair D. Henderson, Atefeh Talebi, Akshay S. Desai, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, Pardeep S. Jhund, John J. V. McMurray
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
heart failure hospitalization
heart failure with reduced ejection fraction (HFrEF)
prognosis
sacubitril/valsartan
sex differences
treatment effect
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.038249
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