Activated platelets stimulate effector CD8+ T cells to enhance HNSCC immunotherapy efficacy

Activated platelets stimulate effector CD8+ T cells to enhance HNSCC immunotherapy efficacy

Abstract Programmed Death Receptor-1 (PD-1) is an immune checkpoint receptor expressed on the surface of T cells. Monoclonal antibodies targeting PD-1 and its ligand, PD-L1, are among the most widely utilized immune checkpoint inhibitors in cancer immunotherapy, dramatically improving the prognosis...

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Bibliographic Details
Main Authors: Zhennan Yuan, Lunhua Guo, Yuheng Pang, Wenjing Wang, Yuefeng Shang, Chufei Xie, Cheng Qian, Ji Sun, Xiaohong Wu
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
HNSCC
PD-1
CyTOF
Platelet
Online Access:https://doi.org/10.1007/s12672-025-02596-y
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