Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal
Background. Clonidine, a central alpha-adrenoreceptor agonist, was initially developed as an antihypertensive. Though no longer commonly used for its original indication due to rebound hypertension after discontinuation, it is currently widely prescribed as a treatment for many pediatric indications...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2022/9005063 |
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| author | Can Cao Matthew L. Lorenz Phillip Sojka Allison W. Brindle Lisa Swartz Topor |
| author_facet | Can Cao Matthew L. Lorenz Phillip Sojka Allison W. Brindle Lisa Swartz Topor |
| author_sort | Can Cao |
| collection | DOAJ |
| description | Background. Clonidine, a central alpha-adrenoreceptor agonist, was initially developed as an antihypertensive. Though no longer commonly used for its original indication due to rebound hypertension after discontinuation, it is currently widely prescribed as a treatment for many pediatric indications including sleep disorders, behavioral concerns, and attention deficit hyperactivity disorder. Case Report. We describe a girl who developed prolonged symptoms of clonidine withdrawal, including hypertension and elevated serum metanephrines. Discussion. Clonidine withdrawal in pediatric patient can present with hypertensive urgency and other signs of sympathetic stimulation. Withdrawal can also lead to dramatic elevation in serum metanephrines. Treatment with a clonidine taper will reduce development of withdrawal symptoms. Conclusion. Given the rise in clonidine use in pediatric patients, clinicians should be aware of the risk of clonidine withdrawal and how to recognize and avoid its development. |
| format | Article |
| id | doaj-art-76f6c7e1f38f403b823e49b3d0d4a853 |
| institution | OA Journals |
| issn | 2090-6811 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-76f6c7e1f38f403b823e49b3d0d4a8532025-08-20T02:07:35ZengWileyCase Reports in Pediatrics2090-68112022-01-01202210.1155/2022/9005063Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine WithdrawalCan Cao0Matthew L. Lorenz1Phillip Sojka2Allison W. Brindle3Lisa Swartz Topor4The Warren Alpert Medical School of Brown UniversityThe Warren Alpert Medical School of Brown UniversityThe Warren Alpert Medical School of Brown UniversityThe Warren Alpert Medical School of Brown UniversityThe Warren Alpert Medical School of Brown UniversityBackground. Clonidine, a central alpha-adrenoreceptor agonist, was initially developed as an antihypertensive. Though no longer commonly used for its original indication due to rebound hypertension after discontinuation, it is currently widely prescribed as a treatment for many pediatric indications including sleep disorders, behavioral concerns, and attention deficit hyperactivity disorder. Case Report. We describe a girl who developed prolonged symptoms of clonidine withdrawal, including hypertension and elevated serum metanephrines. Discussion. Clonidine withdrawal in pediatric patient can present with hypertensive urgency and other signs of sympathetic stimulation. Withdrawal can also lead to dramatic elevation in serum metanephrines. Treatment with a clonidine taper will reduce development of withdrawal symptoms. Conclusion. Given the rise in clonidine use in pediatric patients, clinicians should be aware of the risk of clonidine withdrawal and how to recognize and avoid its development.http://dx.doi.org/10.1155/2022/9005063 |
| spellingShingle | Can Cao Matthew L. Lorenz Phillip Sojka Allison W. Brindle Lisa Swartz Topor Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal Case Reports in Pediatrics |
| title | Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal |
| title_full | Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal |
| title_fullStr | Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal |
| title_full_unstemmed | Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal |
| title_short | Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal |
| title_sort | hypertensive crisis in a pediatric patient experiencing clonidine withdrawal |
| url | http://dx.doi.org/10.1155/2022/9005063 |
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