Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf
<b>Objectives</b>: The study evaluated the impact of revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), during the index hospitalization on major adverse cardiovascular events (MACE) in patients with non-ST-elevation...
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MDPI AG
2025-03-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/12/4/117 |
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| author | Ibrahim Al-Zakwani Fahad AlKindi Wael Almahmeed Mohammad Zubaid |
| author_facet | Ibrahim Al-Zakwani Fahad AlKindi Wael Almahmeed Mohammad Zubaid |
| author_sort | Ibrahim Al-Zakwani |
| collection | DOAJ |
| description | <b>Objectives</b>: The study evaluated the impact of revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), during the index hospitalization on major adverse cardiovascular events (MACE) in patients with non-ST-elevation myocardial infarction (NSTEMI) in the Arabian Gulf. <b>Methods</b>: Data were analyzed from 1820 consecutive patients diagnosed with NSTEMI, admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013, and who were discharged alive. <b>Results</b>: Of the patients, 29.1% (n = 529) underwent either PCI (89.8%; n = 475) or CABG (10.2%; n = 54). The matching method (288 PCI/CABG patients were matched with 762 controls that did not undergo PCI/CABG) revealed significant reductions in MACE events among patients who had undergone PCI/CABG (25% vs. 43%; <i>p</i> < 0.001). This decrease was consistent across individual MACE components, including stroke/transient ischemic attack (TIA) (2.4% vs. 7.0%; <i>p</i> = 0.005), all-cause mortality (4.5% vs. 7.0%; <i>p</i> < 0.001) and cardiac-related readmissions (20% vs. 31%; <i>p</i> = 0.001) but not reinfarction (1.7% vs. 1.4%; <i>p</i> = 0.73). <b>Conclusions</b>: The revascularization procedures, PCI/CABG, were associated with significant reductions in annual MACE event rates, specifically lower stroke/TIA, all-cause mortality and cardiac-related readmissions. |
| format | Article |
| id | doaj-art-76f6a8e84fb741c0b3e71356a1675992 |
| institution | DOAJ |
| issn | 2308-3425 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj-art-76f6a8e84fb741c0b3e71356a16759922025-08-20T03:13:58ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252025-03-0112411710.3390/jcdd12040117Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian GulfIbrahim Al-Zakwani0Fahad AlKindi1Wael Almahmeed2Mohammad Zubaid3Department of Pharmacology & Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat 123, OmanSultan Qaboos University Hospital, University Medical City, Muscat 123, OmanHeart & Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab EmiratesDepartment of Medicine, Faculty of Medicine, Kuwait University, Kuwait City 13110, Kuwait<b>Objectives</b>: The study evaluated the impact of revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), during the index hospitalization on major adverse cardiovascular events (MACE) in patients with non-ST-elevation myocardial infarction (NSTEMI) in the Arabian Gulf. <b>Methods</b>: Data were analyzed from 1820 consecutive patients diagnosed with NSTEMI, admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013, and who were discharged alive. <b>Results</b>: Of the patients, 29.1% (n = 529) underwent either PCI (89.8%; n = 475) or CABG (10.2%; n = 54). The matching method (288 PCI/CABG patients were matched with 762 controls that did not undergo PCI/CABG) revealed significant reductions in MACE events among patients who had undergone PCI/CABG (25% vs. 43%; <i>p</i> < 0.001). This decrease was consistent across individual MACE components, including stroke/transient ischemic attack (TIA) (2.4% vs. 7.0%; <i>p</i> = 0.005), all-cause mortality (4.5% vs. 7.0%; <i>p</i> < 0.001) and cardiac-related readmissions (20% vs. 31%; <i>p</i> = 0.001) but not reinfarction (1.7% vs. 1.4%; <i>p</i> = 0.73). <b>Conclusions</b>: The revascularization procedures, PCI/CABG, were associated with significant reductions in annual MACE event rates, specifically lower stroke/TIA, all-cause mortality and cardiac-related readmissions.https://www.mdpi.com/2308-3425/12/4/117percutaneous coronary interventioncoronary artery bypass graftacute coronary syndromestrokemyocardial infarctionmortality |
| spellingShingle | Ibrahim Al-Zakwani Fahad AlKindi Wael Almahmeed Mohammad Zubaid Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf Journal of Cardiovascular Development and Disease percutaneous coronary intervention coronary artery bypass graft acute coronary syndrome stroke myocardial infarction mortality |
| title | Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf |
| title_full | Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf |
| title_fullStr | Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf |
| title_full_unstemmed | Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf |
| title_short | Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf |
| title_sort | impact of revascularization on major adverse cardiovascular events in patients without st elevation myocardial infarction in the arabian gulf |
| topic | percutaneous coronary intervention coronary artery bypass graft acute coronary syndrome stroke myocardial infarction mortality |
| url | https://www.mdpi.com/2308-3425/12/4/117 |
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