Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells
Stem cells play an irreplaceable role in the development, homeostasis, and regeneration of the craniofacial bone. Multiple populations of tissue-resident craniofacial skeletal stem cells have been identified in different stem cell niches, including the cranial periosteum, jawbone marrow, temporomand...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8868593 |
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| _version_ | 1850218838962995200 |
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| author | Geru Zhang Qiwen Li Quan Yuan Shiwen Zhang |
| author_facet | Geru Zhang Qiwen Li Quan Yuan Shiwen Zhang |
| author_sort | Geru Zhang |
| collection | DOAJ |
| description | Stem cells play an irreplaceable role in the development, homeostasis, and regeneration of the craniofacial bone. Multiple populations of tissue-resident craniofacial skeletal stem cells have been identified in different stem cell niches, including the cranial periosteum, jawbone marrow, temporomandibular joint, cranial sutures, and periodontium. These cells exhibit self-renewal and multidirectional differentiation abilities. Here, we summarized the properties of craniofacial skeletal stem cells, based on their spatial distribution. Specifically, we focused on the in vivo genetic fate mapping of stem cells, by exploring specific stem cell markers and observing their lineage commitment in both the homeostatic and regenerative states. Finally, we discussed their application in regenerative medicine. |
| format | Article |
| id | doaj-art-76f672cd6ec64ef09c3a730824e0b9b9 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-76f672cd6ec64ef09c3a730824e0b9b92025-08-20T02:07:35ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88685938868593Spatial Distributions, Characteristics, and Applications of Craniofacial Stem CellsGeru Zhang0Qiwen Li1Quan Yuan2Shiwen Zhang3State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaStem cells play an irreplaceable role in the development, homeostasis, and regeneration of the craniofacial bone. Multiple populations of tissue-resident craniofacial skeletal stem cells have been identified in different stem cell niches, including the cranial periosteum, jawbone marrow, temporomandibular joint, cranial sutures, and periodontium. These cells exhibit self-renewal and multidirectional differentiation abilities. Here, we summarized the properties of craniofacial skeletal stem cells, based on their spatial distribution. Specifically, we focused on the in vivo genetic fate mapping of stem cells, by exploring specific stem cell markers and observing their lineage commitment in both the homeostatic and regenerative states. Finally, we discussed their application in regenerative medicine.http://dx.doi.org/10.1155/2020/8868593 |
| spellingShingle | Geru Zhang Qiwen Li Quan Yuan Shiwen Zhang Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells Stem Cells International |
| title | Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells |
| title_full | Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells |
| title_fullStr | Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells |
| title_full_unstemmed | Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells |
| title_short | Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells |
| title_sort | spatial distributions characteristics and applications of craniofacial stem cells |
| url | http://dx.doi.org/10.1155/2020/8868593 |
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