Ramp Sequence May Explain Synonymous Variant Association with Alzheimer’s Disease in the Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA)

Ramp Sequence May Explain Synonymous Variant Association with Alzheimer’s Disease in the Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA)

<b>Background:</b> The synonymous variant <i>NC_000007.14:g.100373690T>C</i> (<i>rs2405442:T>C</i>) in the Paired Immunoglobulin-like Type 2 Receptor Alpha (<i>PILRA</i>) gene was previously associated with decreased risk for Alzheimer’s disease...

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Bibliographic Details
Main Authors: Justin B. Miller, J. Anthony Brandon, Lauren M. Harmon, Hady W. Sabra, Chloe C. Lucido, Josue D. Gonzalez Murcia, Kayla A. Nations, Samuel H. Payne, Mark T. W. Ebbert, John S. K. Kauwe, Perry G. Ridge
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomedicines
Subjects:
Alzheimer’s disease
ramp sequence
genetic association
codon usage bias
disease association
Online Access:https://www.mdpi.com/2227-9059/13/3/739
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