Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study
Objective: In COVID-19, cytokine storms (CS) result in higher mortality and morbidity. Our study evaluated the rate of cytokine storms among COVID-positive Bangladeshi adults. Methods: From October 2020 to March 2022, this cohort study enrolled both COVID-positive and COVID-negative healthy adults....
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Elsevier
2024-12-01
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| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024165632 |
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| author | Monira Sarmin Fhameda Akter Anika Nawrin Islam Mustafa Mahfuz Subhasish Das Sharifuzzaman S.M. Tafsir Hasan Taufiqur Rahman Bhuiyan Mustafizur Rahman Amran Gazi Fariha Bushra Matin Md Tariqujjaman Lubaba Shahrin Mofakharul Islam Asif Mujtaba Mahmud Sayera Banu Mohammod Jobayer Chisti Firdausi Qadri John David Clemens Tahmeed Ahmed |
| author_facet | Monira Sarmin Fhameda Akter Anika Nawrin Islam Mustafa Mahfuz Subhasish Das Sharifuzzaman S.M. Tafsir Hasan Taufiqur Rahman Bhuiyan Mustafizur Rahman Amran Gazi Fariha Bushra Matin Md Tariqujjaman Lubaba Shahrin Mofakharul Islam Asif Mujtaba Mahmud Sayera Banu Mohammod Jobayer Chisti Firdausi Qadri John David Clemens Tahmeed Ahmed |
| author_sort | Monira Sarmin |
| collection | DOAJ |
| description | Objective: In COVID-19, cytokine storms (CS) result in higher mortality and morbidity. Our study evaluated the rate of cytokine storms among COVID-positive Bangladeshi adults. Methods: From October 2020 to March 2022, this cohort study enrolled both COVID-positive and COVID-negative healthy adults. COVID-positive cases were treated in a makeshift COVID unit of icdr,b Dhaka Hospital. CS was defined as having IL-6 >80 pg/mL or any three of the following: high CRP, ferritin, LDH, D-dimer, or low lymphocyte. Stored plasma samples were tested for the cytokines IL-6, IL-1β, and TNF-α. Results: This study involved 77 participants, 32 were in the severe-critical group, 30 were in the mild-moderate group, and 14 were COVID-negative. Twelve participants in the severe-critical group had CS. Thus, the rate of CS was 37.5 % (12/32). Compared to COVID-19-negative patients, COVID-19-positive patients had higher IL-6 levels, which decreased at discharge except for those dying. Among the COVID-19-positive patients, nine died. For both the mild-moderate and severe-critical patients, IL-6 increased with increasing CRP (p < 0.001). Conclusion: During the COVID-19 pandemic, Bangladeshi adults experienced a surge in cytokine storms. The rate of cytokine storm in Bangladeshi COVID-19-positive adults was 37.5 %. |
| format | Article |
| id | doaj-art-76ef3cb8d72a41f490fef6e4d819c5dc |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj-art-76ef3cb8d72a41f490fef6e4d819c5dc2025-08-20T01:59:30ZengElsevierHeliyon2405-84402024-12-011023e4053210.1016/j.heliyon.2024.e40532Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort studyMonira Sarmin0Fhameda Akter1Anika Nawrin Islam2Mustafa Mahfuz3Subhasish Das4 Sharifuzzaman5S.M. Tafsir Hasan6Taufiqur Rahman Bhuiyan7Mustafizur Rahman8Amran Gazi9Fariha Bushra Matin10Md Tariqujjaman11Lubaba Shahrin12Mofakharul Islam13Asif Mujtaba Mahmud14Sayera Banu15Mohammod Jobayer Chisti16Firdausi Qadri17John David Clemens18Tahmeed Ahmed19Clinical and Diagnostic Services, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh; Nutrition Research Division, icddr,b, BangladeshClinical and Diagnostic Services, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshClinical and Diagnostic Services, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshNutrition Research Division, icddr,b, BangladeshNutrition Research Division, icddr,b, BangladeshClinical and Diagnostic Services, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshNutrition Research Division, icddr,b, BangladeshInfectious Diseases Division, icddr,b, BangladeshAsgar Ali Hospital, Dhaka, BangladeshNutrition Research Division, icddr,b, BangladeshClinical and Diagnostic Services, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshNutrition Research Division, icddr,b, BangladeshClinical and Diagnostic Services, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh; Nutrition Research Division, icddr,b, BangladeshDhaka Community Medical College & Hospital, Mogbazar, Dhaka, BangladeshAsgar Ali Hospital, Dhaka, BangladeshInfectious Diseases Division, icddr,b, BangladeshClinical and Diagnostic Services, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh; Nutrition Research Division, icddr,b, Bangladesh; Corresponding author. Dhaka Hospital, Nutrition Research Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh.Infectious Diseases Division, icddr,b, BangladeshInternational Vaccine Institute, Seoul, South KoreaNutrition Research Division, icddr,b, Bangladesh; Office of Executive Director, icddr,b, BangladeshObjective: In COVID-19, cytokine storms (CS) result in higher mortality and morbidity. Our study evaluated the rate of cytokine storms among COVID-positive Bangladeshi adults. Methods: From October 2020 to March 2022, this cohort study enrolled both COVID-positive and COVID-negative healthy adults. COVID-positive cases were treated in a makeshift COVID unit of icdr,b Dhaka Hospital. CS was defined as having IL-6 >80 pg/mL or any three of the following: high CRP, ferritin, LDH, D-dimer, or low lymphocyte. Stored plasma samples were tested for the cytokines IL-6, IL-1β, and TNF-α. Results: This study involved 77 participants, 32 were in the severe-critical group, 30 were in the mild-moderate group, and 14 were COVID-negative. Twelve participants in the severe-critical group had CS. Thus, the rate of CS was 37.5 % (12/32). Compared to COVID-19-negative patients, COVID-19-positive patients had higher IL-6 levels, which decreased at discharge except for those dying. Among the COVID-19-positive patients, nine died. For both the mild-moderate and severe-critical patients, IL-6 increased with increasing CRP (p < 0.001). Conclusion: During the COVID-19 pandemic, Bangladeshi adults experienced a surge in cytokine storms. The rate of cytokine storm in Bangladeshi COVID-19-positive adults was 37.5 %.http://www.sciencedirect.com/science/article/pii/S2405844024165632 |
| spellingShingle | Monira Sarmin Fhameda Akter Anika Nawrin Islam Mustafa Mahfuz Subhasish Das Sharifuzzaman S.M. Tafsir Hasan Taufiqur Rahman Bhuiyan Mustafizur Rahman Amran Gazi Fariha Bushra Matin Md Tariqujjaman Lubaba Shahrin Mofakharul Islam Asif Mujtaba Mahmud Sayera Banu Mohammod Jobayer Chisti Firdausi Qadri John David Clemens Tahmeed Ahmed Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study Heliyon |
| title | Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study |
| title_full | Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study |
| title_fullStr | Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study |
| title_full_unstemmed | Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study |
| title_short | Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study |
| title_sort | cytokine storm among bangladeshi adults with covid 19 a prospective cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024165632 |
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